@Eric_Fauman I loved the history behind this paper. It all started with a GWAS of malaria in 11,000 African children, which they published in Nature in 2015. They found a single locus that encompassed the glycophorin genes. https://t.co/mRryjrG2d4 https:
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Has natural selection for malaria susceptibility been maintaining human genetic diversity and variation? Identification of a locus of resistance to severe malaria which overlaps with a locus of ancient balancing selection. Paperaday 26: https://t.co/k7zc
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A neat clue as to how balancing selection may favor tightly linked functional genetic diversity (aka gene buddies): human variants impacting malaria resistance are significantly close to, but not within, regions of ancient polymorphisms shared with chimps.
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A novel #locus of resistance to severe #malaria in a region of ancient balancing selection https://t.co/oCHPNjhYEO | via @NatureNews