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Endocrine-Disrupting Activity of Hydraulic Fracturing Chemicals and Adverse Health Outcomes After Prenatal Exposure in Male Mice

Overview of attention for article published in Endocrinology, October 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#1 of 1,779)
  • High Attention Score compared to outputs of the same age (98th percentile)

Mentioned by

news
14 news outlets
blogs
3 blogs
twitter
18 X users
facebook
3 Facebook pages

Citations

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83 Dimensions

Readers on

mendeley
101 Mendeley
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Title
Endocrine-Disrupting Activity of Hydraulic Fracturing Chemicals and Adverse Health Outcomes After Prenatal Exposure in Male Mice
Published in
Endocrinology, October 2015
DOI 10.1210/en.2015-1375
Pubmed ID
Authors

Christopher D. Kassotis, Kara C. Klemp, Danh C. Vu, Chung-Ho Lin, Chun-Xia Meng, Cynthia L. Besch-Williford, Lisa Pinatti, R. Thomas Zoeller, Erma Z. Drobnis, Victoria D. Balise, Chiamaka J. Isiguzo, Michelle A. Williams, Donald E. Tillitt, Susan C. Nagel

Abstract

Oil and natural gas operations have been shown to contaminate surface and ground water with endocrine-disrupting chemicals. In the current study, we fill several gaps in our understanding of the potential environmental impacts related to this process. We measured the endocrine-disrupting activities of 24 chemicals used and/or produced by oil and gas operations for five nuclear receptors using a reporter gene assay in human endometrial cancer cells. We also quantified the concentration of 16 of these chemicals in oil and gas wastewater samples. Finally, we assessed reproductive and developmental outcomes in male C57BL/6J mice after the prenatal exposure to a mixture of these chemicals. We found that 23 commonly used oil and natural gas operation chemicals can activate or inhibit the estrogen, androgen, glucocorticoid, progesterone, and/or thyroid receptors, and mixtures of these chemicals can behave synergistically, additively, or antagonistically in vitro. Prenatal exposure to a mixture of 23 oil and gas operation chemicals at 3, 30, and 300 μ g/kg · d caused decreased sperm counts and increased testes, body, heart, and thymus weights and increased serum T in male mice, suggesting multiple organ system impacts. Our results suggest possible adverse developmental and reproductive health outcomes in humans and animals exposed to potential environmentally relevant levels of oil and gas operation chemicals.

X Demographics

X Demographics

The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Unknown 99 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 16%
Student > Master 14 14%
Student > Bachelor 14 14%
Student > Ph. D. Student 12 12%
Other 10 10%
Other 17 17%
Unknown 18 18%
Readers by discipline Count As %
Environmental Science 17 17%
Agricultural and Biological Sciences 13 13%
Medicine and Dentistry 12 12%
Biochemistry, Genetics and Molecular Biology 6 6%
Chemistry 6 6%
Other 20 20%
Unknown 27 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 135. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2023.
All research outputs
#315,579
of 25,839,971 outputs
Outputs from Endocrinology
#1
of 1,779 outputs
Outputs of similar age
#4,299
of 292,142 outputs
Outputs of similar age from Endocrinology
#1
of 1 outputs
Altmetric has tracked 25,839,971 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,779 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 292,142 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them