Chapter title |
Protein Arginylation
|
---|---|
Chapter number | 6 |
Book title |
Protein Arginylation
|
Published in |
Methods in molecular biology, January 2015
|
DOI | 10.1007/978-1-4939-2935-1_6 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2934-4, 978-1-4939-2935-1
|
Authors |
Kaji, Hideko, Kaji, Akira, Hideko Kaji, Akira Kaji |
Editors |
Anna S. Kashina |
Abstract |
Following our early discovery of arginylation in 1963, we have performed several studies to correlate its activity with essential biological processes. We employed cell- and tissue-based assays to detect both the level of acceptor proteins and the level of ATE1 activity under different conditions. Remarkably, in these assays, we found a close correlation between arginylation and aging, a discovery that we believe has longer-term implications in uncovering the importance of ATE1 in normal biology and disease therapies. Here we describe the original methods we used to measure ATE1 activity in tissues and correlate it with key biological events. |
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