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Persistent Hyperdopaminergia Decreases the Peak Frequency of Hippocampal Theta Oscillations during Quiet Waking and REM Sleep

Overview of attention for article published in PLoS ONE, April 2009
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Mentioned by

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2 tweeters

Citations

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14 Dimensions

Readers on

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58 Mendeley
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Title
Persistent Hyperdopaminergia Decreases the Peak Frequency of Hippocampal Theta Oscillations during Quiet Waking and REM Sleep
Published in
PLoS ONE, April 2009
DOI 10.1371/journal.pone.0005238
Pubmed ID
Authors

Kafui Dzirasa, Lucas M. Santos, Sidarta Ribeiro, Jennifer Stapleton, Raul R. Gainetdinov, Marc G. Caron, Miguel A. L. Nicolelis

Abstract

Long-term changes in dopaminergic signaling are thought to underlie the pathophysiology of a number of psychiatric disorders. Several conditions are associated with cognitive deficits such as disturbances in attention processes and learning and memory, suggesting that persistent changes in dopaminergic signaling may alter neural mechanisms underlying these processes. Dopamine transporter knockout (DAT-KO) mice exhibit a persistent five-fold increase in extracellular dopamine levels. Here, we demonstrate that DAT-KO mice display lower hippocampal theta oscillation frequencies during baseline periods of waking and rapid-eye movement sleep. These altered theta oscillations are not reversed via treatment with the antidopaminergic agent haloperidol. Thus, we propose that persistent hyperdopaminergia, together with secondary alterations in other neuromodulatory systems, results in lower frequency activity in neural systems responsible for various cognitive processes.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 2 3%
Netherlands 1 2%
United States 1 2%
Brazil 1 2%
Unknown 53 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 28%
Researcher 9 16%
Professor > Associate Professor 7 12%
Student > Doctoral Student 6 10%
Student > Master 6 10%
Other 9 16%
Unknown 5 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 24%
Neuroscience 14 24%
Medicine and Dentistry 8 14%
Engineering 6 10%
Psychology 6 10%
Other 1 2%
Unknown 9 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2013.
All research outputs
#7,138,462
of 12,367,413 outputs
Outputs from PLoS ONE
#69,621
of 135,596 outputs
Outputs of similar age
#102,408
of 216,865 outputs
Outputs of similar age from PLoS ONE
#1,770
of 3,637 outputs
Altmetric has tracked 12,367,413 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 135,596 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.7. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 216,865 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 3,637 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.