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Composition, variability, and temporal stability of the intestinal microbiota of the elderly

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, June 2010
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
2 news outlets
blogs
1 blog
policy
2 policy sources
twitter
6 tweeters
patent
4 patents
facebook
1 Facebook page

Citations

dimensions_citation
1188 Dimensions

Readers on

mendeley
1368 Mendeley
citeulike
9 CiteULike
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Title
Composition, variability, and temporal stability of the intestinal microbiota of the elderly
Published in
Proceedings of the National Academy of Sciences of the United States of America, June 2010
DOI 10.1073/pnas.1000097107
Pubmed ID
Authors

Marcus J. Claesson, Siobhán Cusack, Orla O'Sullivan, Rachel Greene-Diniz, Heleen de Weerd, Edel Flannery, Julian R. Marchesi, Daniel Falush, Timothy Dinan, Gerald Fitzgerald, Catherine Stanton, Douwe van Sinderen, Michael O'Connor, Norma Harnedy, Kieran O'Connor, Colm Henry, Denis O'Mahony, Anthony P. Fitzgerald, Fergus Shanahan, Cillian Twomey, Colin Hill, R. Paul Ross, Paul W. O'Toole

Abstract

Alterations in the human intestinal microbiota are linked to conditions including inflammatory bowel disease, irritable bowel syndrome, and obesity. The microbiota also undergoes substantial changes at the extremes of life, in infants and older people, the ramifications of which are still being explored. We applied pyrosequencing of over 40,000 16S rRNA gene V4 region amplicons per subject to characterize the fecal microbiota in 161 subjects aged 65 y and older and 9 younger control subjects. The microbiota of each individual subject constituted a unique profile that was separable from all others. In 68% of the individuals, the microbiota was dominated by phylum Bacteroides, with an average proportion of 57% across all 161 baseline samples. Phylum Firmicutes had an average proportion of 40%. The proportions of some phyla and genera associated with disease or health also varied dramatically, including Proteobacteria, Actinobacteria, and Faecalibacteria. The core microbiota of elderly subjects was distinct from that previously established for younger adults, with a greater proportion of Bacteroides spp. and distinct abundance patterns of Clostridium groups. Analyses of 26 fecal microbiota datasets from 3-month follow-up samples indicated that in 85% of the subjects, the microbiota composition was more like the corresponding time-0 sample than any other dataset. We conclude that the fecal microbiota of the elderly shows temporal stability over limited time in the majority of subjects but is characterized by unusual phylum proportions and extreme variability.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 1,368 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 14 1%
United Kingdom 6 <1%
Spain 5 <1%
Denmark 3 <1%
Italy 3 <1%
Netherlands 2 <1%
France 2 <1%
Korea, Republic of 2 <1%
Germany 2 <1%
Other 12 <1%
Unknown 1317 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 239 17%
Student > Ph. D. Student 236 17%
Student > Master 198 14%
Student > Bachelor 186 14%
Student > Doctoral Student 63 5%
Other 212 15%
Unknown 234 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 401 29%
Biochemistry, Genetics and Molecular Biology 190 14%
Medicine and Dentistry 177 13%
Immunology and Microbiology 107 8%
Nursing and Health Professions 40 3%
Other 169 12%
Unknown 284 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 46. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2021.
All research outputs
#716,245
of 21,619,833 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#12,284
of 95,830 outputs
Outputs of similar age
#4,985
of 248,284 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#65
of 705 outputs
Altmetric has tracked 21,619,833 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 95,830 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 34.7. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 248,284 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 705 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.