Chapter title |
Glucocorticoids and the Lung
|
---|---|
Chapter number | 12 |
Book title |
Glucocorticoid Signaling
|
Published in |
Advances in experimental medicine and biology, January 2015
|
DOI | 10.1007/978-1-4939-2895-8_12 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2894-1, 978-1-4939-2895-8
|
Authors |
Gerber, Anthony N., Anthony N. Gerber |
Abstract |
The lung is a major clinical target of glucocorticoid-based therapeutics, and GR signaling has broad effects on respiratory physiology and inflammation. During lung development, expression of GR in the mesenchyme is required for normal terminal alveolar epithelial differentiation. Prenatal administration of exogenous glucocorticoids (GCs) to prevent neonatal respiratory distress syndrome, however, promotes alveolar maturation and accelerates surfactant expression in a manner consistent with direct effects on the developing alveolar epithelium. Likewise, cell autonomous effects of GCs in regulating gene expression and phenotype of the airway epithelium and airway smooth muscle have been demonstrated to control important therapeutic effects of GCs in treating asthma and chronic obstructive pulmonary disease. Here, mechanisms and consequences of GR signaling in the developing lung and in treating obstructive lung disease are reviewed, with a focus on direct effects of GR signaling on alveolar differentiation, surfactant expression, and airway epithelial and smooth muscle pathophysiology. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 29 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 7 | 24% |
Student > Master | 6 | 21% |
Librarian | 2 | 7% |
Student > Ph. D. Student | 2 | 7% |
Student > Doctoral Student | 2 | 7% |
Other | 4 | 14% |
Unknown | 6 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 38% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Computer Science | 2 | 7% |
Agricultural and Biological Sciences | 1 | 3% |
Arts and Humanities | 1 | 3% |
Other | 4 | 14% |
Unknown | 8 | 28% |