Chapter title |
Kynurenines, redox disturbances and neurodegeneration in multiple sclerosis.
|
---|---|
Chapter number | 40 |
Book title |
Neuropsychiatric Disorders An Integrative Approach
|
Published in |
Journal of neural transmission Supplementum, January 2007
|
DOI | 10.1007/978-3-211-73574-9_40 |
Pubmed ID | |
Book ISBNs |
978-3-21-173573-2, 978-3-21-173574-9
|
Authors |
Rajda, C, Bergquist, J, Vécsei, L, C. Rajda, J. Bergquist, L. Vécsei, Rajda, C., Bergquist, J., Vécsei, L. |
Abstract |
Multiple sclerosis (MS) is a chronic, demyelinating disease of unknown origin. Sophisticated analytical methods have made it possible to measure small biologically active molecules at low endogenous levels, and understand their role in the network of other biologically active compounds actively involved in inflammatory and neurodegenerative processes. Evidence is accumulating as concerns the disturbances of the kynurenine pathway and redox changes in MS. A new promising metabolite of the kynurenine pathway seems to beneficially influence experimental allergic encephalomyelitis. More clinical evidence is needed to prove the role of kynurenic acid analogues and/or enzyme inhibitors as potential medications in MS in the future. Various compounds have been shown to be important in the pathophysiological processes of the disease and are targets for pharmaceutical intervention. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 6% |
Spain | 1 | 6% |
Unknown | 16 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 28% |
Student > Master | 3 | 17% |
Other | 2 | 11% |
Professor | 2 | 11% |
Student > Doctoral Student | 1 | 6% |
Other | 2 | 11% |
Unknown | 3 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 33% |
Agricultural and Biological Sciences | 3 | 17% |
Neuroscience | 3 | 17% |
Immunology and Microbiology | 1 | 6% |
Chemistry | 1 | 6% |
Other | 1 | 6% |
Unknown | 3 | 17% |