| Chapter title |
Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach.
|
|---|---|
| Chapter number | 28 |
| Book title |
Neuropsychiatric Disorders An Integrative Approach
|
| Published in |
Journal of neural transmission Supplementum, January 2007
|
| DOI | 10.1007/978-3-211-73574-9_28 |
| Pubmed ID | |
| Book ISBNs |
978-3-21-173573-2, 978-3-21-173574-9
|
| Authors |
M Salkovic-Petrisic, S Hoyer, Salkovic-Petrisic, M, Hoyer, S, M. Salkovic-Petrisic, S. Hoyer, Salkovic-Petrisic, M., Hoyer, S. |
| Abstract |
A growing body of evidence implicates impairments in brain insulin signaling in early sporadic Alzheimer disease (sAD) pathology. However, the most widely accepted hypothesis for AD aetiology stipulates that pathological aggregations of the amyloid beta (Abeta) peptide are the cause of all forms of Alzheimer's disease. Streptozotocin-intracerebroventricularly (STZ-icv) treated rats are proposed as a probable experimental model of sAD. The current work reviews evidence obtained from this model indicating that central STZ administration induces brain pathology and behavioural alterations resembling those in sAD patients. Recently, alterations of the brain insulin system resembling those in sAD have been found in the STZ-icv rat model and are associated with tau protein hyperphosphorylation and Abeta-like aggregations in meningeal vessels. In line with these findings the hypothesis has been proposed that insulin resistance in the brain might be the primary event which precedes the Abeta pathology in sAD. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Croatia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| United Kingdom | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Croatia | 1 | <1% |
| Unknown | 179 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 16% |
| Researcher | 28 | 15% |
| Student > Master | 27 | 15% |
| Student > Bachelor | 18 | 10% |
| Student > Doctoral Student | 11 | 6% |
| Other | 38 | 21% |
| Unknown | 33 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 18% |
| Neuroscience | 33 | 18% |
| Medicine and Dentistry | 30 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 8% |
| Biochemistry, Genetics and Molecular Biology | 13 | 7% |
| Other | 14 | 8% |
| Unknown | 46 | 25% |