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A novel host-responsive sensor mediates virulence and type III secretion during Pseudomonas aeruginosa–host cell interactions

Overview of attention for article published in Microbiology, January 2012
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  • Good Attention Score compared to outputs of the same age (76th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

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2 X users
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3 patents

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25 Dimensions

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43 Mendeley
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Title
A novel host-responsive sensor mediates virulence and type III secretion during Pseudomonas aeruginosa–host cell interactions
Published in
Microbiology, January 2012
DOI 10.1099/mic.0.056127-0
Pubmed ID
Authors

Julie O'Callaghan, F Jerry Reen, Claire Adams, Pat G Casey, Cormac G M Gahan, Fergal O'Gara

Abstract

Sensitive sensory mechanisms are instrumental in affording Pseudomonas aeruginosa the capacity to establish diverse yet severe human infections, which can manifest themselves in long-term untreatable disease. The ability of P. aeruginosa to tightly regulate gene expression and virulence factor production, in response to activation of these sensory components, enables the pathogen to sustain infection despite the host immune response and aggressive antibiotic treatment. Although a number of factors are recognized as playing a role in early infection, very little is known regarding the sensors involved in this process. In this study, we identified P. aeruginosa PA3191 as a novel host-responsive sensor that plays a key role during P. aeruginosa-host interactions and is required for optimum colonization and dissemination in a mouse model of infection. We demonstrated that PA3191 contributed to modulation of the type III secretion system (T3SS) in response to host cells and T3SS-inducing conditions in vitro. PA3191 (designated GtrS) acted in concert with the response regulator GltR to regulate the OprB transport system and subsequently carbon metabolism. Through this signal transduction pathway, T3SS activation was mediated via the RsmAYZ regulatory cascade and involved the global anaerobic response regulator Anr.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Poland 1 2%
Unknown 42 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 26%
Researcher 10 23%
Student > Bachelor 3 7%
Other 3 7%
Professor > Associate Professor 3 7%
Other 7 16%
Unknown 6 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 42%
Biochemistry, Genetics and Molecular Biology 7 16%
Immunology and Microbiology 7 16%
Nursing and Health Professions 1 2%
Environmental Science 1 2%
Other 3 7%
Unknown 6 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2020.
All research outputs
#7,047,002
of 25,373,627 outputs
Outputs from Microbiology
#1,802
of 5,709 outputs
Outputs of similar age
#58,317
of 251,408 outputs
Outputs of similar age from Microbiology
#6
of 30 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 5,709 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,408 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.