| Chapter title |
A Guideline for the Annotation of UTR Regulatory Elements in the UTRsite Collection
|
|---|---|
| Chapter number | 21 |
| Book title |
RNA Bioinformatics
|
| Published in |
Methods in molecular biology, December 2014
|
| DOI | 10.1007/978-1-4939-2291-8_21 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-2290-1, 978-1-4939-2291-8
|
| Authors |
Matteo Giulietti, Giorgio Grillo, Sabino Liuni, Graziano Pesole |
| Editors |
Ernesto Picardi |
| Abstract |
Gene expression regulatory elements are scattered in gene promoters and pre-mRNAs. In particular, RNA elements lying in untranslated regions (5' and 3'UTRs) are poorly studied because of their peculiar features (i.e., a combination of primary and secondary structure elements) which also pose remarkable computational challenges. Several years ago, we began collecting experimentally characterized UTR regulatory elements, developing the specialized database UTRsite. This paper describes the detailed guidelines to annotate cis-regulatory elements in 5' and 3' UnTranslated Regions (UTRs) by computational analyses, retracing all main steps used by UTRsite curators. |
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Demographic breakdown
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|---|---|---|
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