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Vaccine Design

Overview of attention for book
Cover of 'Vaccine Design'

Table of Contents

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    Book Overview
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    Chapter 1 Challenges in Veterinary Vaccine Development and Immunization.
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    Chapter 2 Development of Mycoplasma hyopneumoniae Recombinant Vaccines.
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    Chapter 3 Computational Prediction of Immunodominant Epitopes on Outer Membrane Protein (Omp) H of Pasteurella multocida Toward Designing of a Peptide Vaccine.
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    Chapter 4 DNA Vaccines Against Maedi-Visna Virus.
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    Chapter 5 Detection of Avian Antigen-Specific T Cells Induced by Viral Vaccines.
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    Chapter 6 Generation of Newcastle Disease Virus (NDV) Recombinants Expressing the Infectious Laryngotracheitis Virus (ILTV) Glycoprotein gB or gD as Dual Vaccines.
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    Chapter 7 Vaccine Design
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    Chapter 8 Development of Fasciola Vaccine in an Animal Model.
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    Chapter 9 Development of Experimental Vaccines Against Liver Flukes.
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    Chapter 10 Vaccine Design
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    Chapter 11 DNA Vaccination in Chickens.
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    Chapter 12 Selection of Vaccine Candidates for Fish Pasteurellosis Using Reverse Vaccinology and an In Vitro Screening Approach.
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    Chapter 13 Development of Vaccines Against Nocardiosis in Fishes.
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    Chapter 14 Design of an Immersion Vaccine Against Aeromonad Septicemia in Perch (Perca fluviatilis L.).
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    Chapter 15 Prokaryotic Production of Virus-Like Particle Vaccine of Betanodavirus.
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    Chapter 16 Design and Construction of Shrimp Antiviral DNA Vaccines Expressing Long and Short Hairpins for Protection by RNA Interference.
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    Chapter 17 Developing Anti-tick Vaccines.
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    Chapter 18 Host Immunization with Recombinant Proteins to Screen Antigens for Tick Control.
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    Chapter 19 Vaccinomics Approach to Tick Vaccine Development.
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    Chapter 20 Vaccine Design
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    Chapter 21 Vaccine Design
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    Chapter 22 Alphavirus-Based Vaccines.
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    Chapter 23 Vaccine Design: Replication-Defective Adenovirus Vectors.
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    Chapter 24 Generation of Lymphocytic Choriomeningitis Virus Based Vaccine Vectors.
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    Chapter 25 Production of Japanese Encephalitis Virus-Like Particles Using Insect Cell Expression Systems.
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    Chapter 26 Subunit Protein Vaccine Delivery System for Tuberculosis Based on Hepatitis B Virus Core VLP (HBc-VLP) Particles.
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    Chapter 27 Formulation Studies During Preclinical Development of Influenza Hemagglutinin and Virus-Like Particle Vaccine Candidates.
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    Chapter 28 Strategies for Vaccine Design Using Phage Display-Derived Peptides.
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    Chapter 29 Production of Well-Characterized Virus-like Particles in an Escherichia coli-Based Expression Platform for Preclinical Vaccine Assessments.
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    Chapter 30 Vaccine Design
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    Chapter 31 Vaccine Design
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    Chapter 32 Vaccine Design
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    Chapter 33 Facile Method for the Production of Recombinant Cholera Toxin B Subunit in E. coli.
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    Chapter 34 Immunoproteomic Approach for Screening Vaccine Candidates from Bacterial Outer Membrane Proteins.
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    Chapter 35 Vaccine Design
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    Chapter 36 Oral Rabies Vaccine Design for Expression in Plants.
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    Chapter 37 Purification of Virus-Like Particles (VLPs) from Plants.
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    Chapter 38 Transient Expression of Viral Proteins in Plants Using Agrobacterium tumefaciens.
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    Chapter 39 Vaccine Design
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    Chapter 40 Recombinant Botulinum Toxoids: A Practical Guide for Production.
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    Chapter 41 Preparation of Multifunctional Liposomes as a Stable Vaccine Delivery-Adjuvant System by Procedure of Emulsification-Lyophilization.
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    Chapter 42 Preparation of the Multifunctional Liposome-Containing Microneedle Arrays as an Oral Cavity Mucosal Vaccine Adjuvant-Delivery System.
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    Chapter 43 Preparation and Characterization of PLGA Encapsulated Protective Antigen Domain 4 Nanoformulation.
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    Chapter 44 Attenuated Salmonella sp. as a DNA Delivery System for Trypanosoma cruzi Antigens.
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    Chapter 45 Poly-ε-caprolactone/Chitosan and Chitosan Particles: Two Recombinant Antigen Delivery Systems for Intranasal Vaccination.
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    Chapter 46 Micro-fractional Epidermal Powder Delivery for Skin Vaccination.
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    Chapter 47 Vaccine Design
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    Chapter 48 The Web-Based DNA Vaccine Database DNAVaxDB and Its Usage for Rational DNA Vaccine Design.
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    Chapter 49 MetaMHCpan, A Meta Approach for Pan-Specific MHC Peptide Binding Prediction.
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    Chapter 50 A Cohesive and Integrated Platform for Immunogenicity Prediction.
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    Chapter 51 The Regulatory Evaluation of Vaccines for Human Use.
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    Chapter 52 Vaccines and IP Rights: A Multifaceted Relationship.
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    Chapter 53 From the Bench to the Pharmacy: Protecting Innovation During Vaccine Development and Commercialization.
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    Chapter 54 Intellectual Property in Vaccine Innovation: Impact of Recent Patent Developments.
Attention for Chapter 46: Micro-fractional Epidermal Powder Delivery for Skin Vaccination.
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Chapter title
Micro-fractional Epidermal Powder Delivery for Skin Vaccination.
Chapter number 46
Book title
Vaccine Design
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-3389-1_46
Pubmed ID
27076332
Book ISBNs
978-1-4939-3388-4, 978-1-4939-3389-1
Authors

Feng Jia, Shengwu Liu, Mei X. Wu, Xinyuan Chen

Editors

Sunil Thomas

Abstract

Skin is a highly immunogenic site for vaccine delivery due to its richness of antigen-presenting cells. Several vaccines have been approved for skin delivery and in particular intradermal delivery in the last two decades. Yet intradermal delivery often causes frequent and severe local reactions, preventing the incorporation of adjuvants to further boost skin vaccination. Here we describe a novel skin delivery technology, called micro-fractional epidermal powder delivery or EPD, with minimized local reactions for improved skin vaccination. EPD is based on laser or microneedle treatment to generate microchannel arrays in the epidermis followed by topical application of powder vaccine-coated array patches to deliver vaccines into the skin via microchannels. Due to the fractional delivery, EPD significantly reduces vaccine/adjuvant-induced local reactions without compromising vaccine immunogenicity and adjuvant potency. EPD also eliminates needle injection-associated pain and is promising to improve vaccine stability due to the direct powder delivery. This chapter describes detailed methods for the advantageous EPD in preclinical animal models.

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Mendeley readers

The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 5 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 1 20%
Other 1 20%
Student > Doctoral Student 1 20%
Student > Master 1 20%
Unknown 1 20%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 2 40%
Materials Science 1 20%
Medicine and Dentistry 1 20%
Unknown 1 20%

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