RT @renesugar: "These antioxidants (mitoquinol (MitoQ) or thiol reductant N-acetyl cysteine (NAC)) also prevented the upregulation of TNF-α…
@Christina_Wood1 @latkedelrey @ahandvanish @Mito_Q The amount of NAC likely to make any difference would be based upon weight (grams/day). eg. https://t.co/9EuZlJX16R "capsules of glycine (1.33 mmol/kg/day) and cysteine (0.81 mmol/kg/day, provided as N‐
RT @insulin_resista: تفاقم الامراض الفيروسية وخاصة التي تصيب الرئة وصعوبة السيطرة عليها لدى الناس الذين لديهم سكر٢ غير منضبط https://t.co/…
RT @insulin_resista: تفاقم الامراض الفيروسية وخاصة التي تصيب الرئة وصعوبة السيطرة عليها لدى الناس الذين لديهم سكر٢ غير منضبط https://t.co/…
تفاقم الامراض الفيروسية وخاصة التي تصيب الرئة وصعوبة السيطرة عليها لدى الناس الذين لديهم سكر٢ غير منضبط https://t.co/nHgfeuqfUq https://t.co/Z6NiNu0i7V
RT @ChrisMasterjohn: Monocytes are highly glycolytic: https://t.co/2zGI3BZR5k
Monocytes are highly glycolytic: https://t.co/2zGI3BZR5k
ORF3a 感染細胞apoptosis 癌退行か進行⬆️ https://t.co/vx7ILhJ2e2 免疫回避 https://t.co/Wu3WULD9L0 急性腎障害 https://t.co/HNeeJTjbPX 血糖値⬆️とHIF-1α https://t.co/8W2be3Qtg0
RT @ltkagohara: Insightful paper on why diabetes is a risk factor for COVID-19. Glucose increases virus replication and cytokines productio…
@WesElyMD @Nature May be of interest: https://t.co/4TAPQyEq0f
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis https://t.co/vnn4LOEd6i
@QuackDetector Lol, you must have the dumbest of followers. What are all they up to? 6th shot? https://t.co/42PnvYDLnq
@qtpocopony @MONTMAN9500 @suemidd58863059 @TheChiefNerd Here is another: https://t.co/D30Ygf8Ug5
Exploration of mechanisms helps explain complex scientific processes which convinces scientists, who truly believe in logic, of how one leads to another, what goes wrong during adverse conditions & how to fix them.Without knowing the mechanism, we cann
"These antioxidants (mitoquinol (MitoQ) or thiol reductant N-acetyl cysteine (NAC)) also prevented the upregulation of TNF-α; IL-6; IFN α, β, and λ; and HIF-1α target genes" https://t.co/KyNnkGnBXV
RT @renesugar: https://t.co/MZNAuJOJZt "In conclusion, we showed that #SARSCoV2-infected monocytes express large amounts of proinflammator…
RT @renesugar: https://t.co/MZNAuJOJZt "These antioxidants also prevented the upregulation of TNF-α; IL-6; IFN α, β, and λ; and HIF-1α tar…
RT @renesugar: https://t.co/MZNAuJOJZt "Treatment of #SARSCoV2-infected monocytes with antioxidants, such as mitoquinol (MitoQ) or thiol r…
血糖値⬆️はHIF-1α/解糖依存軸 ⇨SARS-CoV-2感染と単球応答⬆️ https://t.co/OQQcuZA9UU 血糖値⬆️は単球における🦠複製とcytokine産生を調節 解糖系はコロナによる単球応答と🦠複製を維持 mtROS/HIF-1αはCoV-2複製と単球cytokine産生に必要 単球由来cytokineがT細胞の機能不全と上皮細胞死⬆️ https://t.co/zpsZ4Mh0Cc
https://t.co/MZNAuJOJZt "These data may explain why uncontrolled diabetes may lead to compromised adaptive immune response and lung dysfunction in patients with severe #COVID19 symptoms."
https://t.co/MZNAuJOJZt "Finally, we demonstrate that #SARSCoV2-infected monocytes promote T cell dysfunction and lung epithelial cell death."
https://t.co/MZNAuJOJZt "Glycolytic flux is required for #SARSCoV2 replication." #SARSCoV2-induced mtROS production stabilizes HIF-1α, which in turn upregulates glycolytic genes and IL-1β expression."
https://t.co/MZNAuJOJZt "In conclusion, we showed that #SARSCoV2-infected monocytes express large amounts of proinflammatory cytokines and IFNs." "Elevated glucose levels directly induce viral replication and proinflammatory cytokine expression."
https://t.co/MZNAuJOJZt "These results provide evidence to explain why elevated glucose levels during #SARSCoV2 infection may lead to T cell dysfunction and lymphopenia."
https://t.co/MZNAuJOJZt "CM-CoV-2 increased PD-1 expression by CD4 T cells, and this was reversed in CM-BAY87, CM-MitoQ, and CM-IL-1β"
https://t.co/MZNAuJOJZt "These antioxidants also prevented the upregulation of TNF-α; IL-6; IFN α, β, and λ; and HIF-1α target genes" "Persistent viral infections are associated with increased PD-1 expression, a marker of T cell exhaustion"
https://t.co/MZNAuJOJZt "Treatment of #SARSCoV2-infected monocytes with antioxidants, such as mitoquinol (MitoQ) or thiol reductant N-acetyl cysteine (NAC), was sufficient to inhibit viral replication and #SARSCoV2-induced HIF-1α stabilization and express
https://t.co/MZNAuJOJZt "HIF-1α-induced changes in monocyte metabolism by #SARSCoV2 infection directly inhibit T cell response and reduce epithelial cell survival." "Targeting HIF-1ɑ may have great therapeutic potential for the development of novel drugs
https://t.co/MZNAuJOJZt "The infection triggers mitochondrial ROS production, which induces stabilization of hypoxia-inducible factor-1α (HIF-1α) and consequently promotes glycolysis."
https://t.co/MZNAuJOJZt "These cells adapt their metabolism upon infection and become highly glycolytic, which facilitates #SARSCoV2 replication."
https://t.co/MZNAuJOJZt "Monocytes and macrophages are the most enriched immune cell types in the lungs of #COVID19 patients and appear to have a central role in the pathogenicity of the disease."
https://t.co/MZNAuJOJZt "- mtROS/HIF-1α is necessary for #SARSCoV2 replication and monocyte cytokine production - Monocyte-derived cytokines drive T cell dysfunction and epithelial cell death"
https://t.co/MZNAuJOJZt "- Elevated glucose levels regulate viral replication and cytokine production in monocytes - Glycolysis sustains #SARSCoV2-induced monocyte response and viral replication"
Elevated Glucose Levels Favor #SARSCoV2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis https://t.co/5VIFHGDrp7
RT @DrSunitKSingh: Connection between Glucose levels and COVID-19 Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response…
https://t.co/alRc65iJZv 「高グルコースレベルは、HIF-1α/解糖依存性の軸を通してSARS-CoV-2感染と単球応答を促進する」
https://t.co/alRc65iJZv 「SARS-CoV-2の感染と単球の反応にグルコースレベルの上昇がHIF-1α/解糖依存的に寄与していること」
@RolandBakerIII @loafingcactus Not really about the confounding, sorry From what I read, it has many times looked to me as if metforming would help modulating host response to infection, inhibiting mTOR, hence creating an hostile env for viral replication
@Operation_Ivy26 @thien3000 @DefiantLs Hmmm. Your lifestyle has a huge impact on your likelihood of contracting and there4 spreading covid. Covid selects for the glucose pathways, elevated in obese people. Your lifestyle can in fact make you a super-spread
RT @DrLBoominathan: 8. How do elevated Glucose Levels Favor SARS-CoV-2 Infection? Elevated Glucose levels, induce HIF1α, which in turn, ind…
@yaneerbaryam @CartlandDavid This study from 2020 found that elevated glucose levels increase susceptibility to SARS-CoV-2 through the HIF-1a pathway: https://t.co/3JDb69yiY9
RT @AleTrainerxxx: Questi antiossidanti hanno anche impedito la sovra regolazione del TNF-α; IL-6; IFN α, β e λ; e geni bersaglio HIF-1α.…
RT @AleTrainerxxx: Questi antiossidanti hanno anche impedito la sovra regolazione del TNF-α; IL-6; IFN α, β e λ; e geni bersaglio HIF-1α.…
Questi antiossidanti hanno anche impedito la sovra regolazione del TNF-α; IL-6; IFN α, β e λ; e geni bersaglio HIF-1α. ‼️👇 https://t.co/DhcqLPgrhn
@schmucksidyboy @2WaysToPlay @kevinbrownnc @DanCrenshawTX Don't tell me you didn't ask yourself why the obese are so overly represented? Gluttony most certainly is contagious when Covid selects for glucose. Basic concepts.......https://t.co/aIvSi4qP3k
RT @DorissLoh: Apparently, SARS-CoV-2 can upregulate glycolysis and suppress OXPHOS in mitochondria. 2/4 https://t.co/vUVfYOfavJ
RT @DorissLoh: Apparently, SARS-CoV-2 can upregulate glycolysis and suppress OXPHOS in mitochondria. 2/4 https://t.co/vUVfYOfavJ
Apparently, SARS-CoV-2 can upregulate glycolysis and suppress OXPHOS in mitochondria. 2/4 https://t.co/vUVfYOfavJ
Remember that COVID increases glucose overall via glycoprotein 73, increased release of cortisol, metabolic dysfunction, and changes in glycolysis and glycolytic pathway too. https://t.co/EJu6rmuk3F https://t.co/LwxT3gL2rd https://t.co/UJw8CYmvYt
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis https://t.co/1mSDNl2v7m
RT @BlackSanta911: @fynn_fan Top experts are fully aware that elevated blood glucose levels give SC2 the advantage of infection/replication…
RT @BlackSanta911: @fynn_fan Top experts are fully aware that elevated blood glucose levels give SC2 the advantage of infection/replication…
RT @BlackSanta911: @fynn_fan Top experts are fully aware that elevated blood glucose levels give SC2 the advantage of infection/replication…
RT @BlackSanta911: @fynn_fan Top experts are fully aware that elevated blood glucose levels give SC2 the advantage of infection/replication…
RT @BlackSanta911: @fynn_fan Top experts are fully aware that elevated blood glucose levels give SC2 the advantage of infection/replication…
RT @BlackSanta911: @fynn_fan Top experts are fully aware that elevated blood glucose levels give SC2 the advantage of infection/replication…
“Government spends $4 BILLION every year subsidizing sugar production...” https://t.co/QqeEHbQui5
RT @mdeatherage76: 'Here we show that elevated glucose and sustained aerobic glycolysis in monocytes directly promote viral replication, cy…
@ZubyMusic @dan_janky Obesity is contagious - literally - in the context of covid. "Elevated Glucose Levels Favor SARS-CoV-2 Infection" - eating habits affect transmissibility and contagiousness. It's why the obese/diabetics were overly represented. https:
@Tanto_Archilo @DarrenJBeattie "Elevated Glucose Levels Favor SARS-CoV-2 Infection" - in the context of Covid eating habits certainly affect transmissibility and contribute to the pandemic. Surely you wondered why the obese were overly represented? https:/
RT @tom_sarega: @AIWinGold @Tamara_uni @abiroberts "Elevated Glucose Levels Favor SARS-CoV-2 Infection". The context discussed is covid. In…
@AIWinGold @Tamara_uni @abiroberts "Elevated Glucose Levels Favor SARS-CoV-2 Infection". The context discussed is covid. In that context eating habits definitely affect contagiousness of the disease - that's why they're over-represented. https://t.co/FmwtQ
@StephanKesting Something to consider to reduce the odds...might be worth a deep dive. Also goes hand in hand with our obesity discussion. Good luck, https://t.co/ck7BDoGcCn
"HIF-1α-induced changes in monocyte metabolism by SARS-CoV-2 infection directly inhibit T cell response and reduce epithelial cell survival" https://t.co/1mSDNl2v7m https://t.co/6ySOYVgCcD https://t.co/ZGNRi4CquW @DrLBoominathan
https://t.co/1mSDNl2v7m "The infection triggers mitochondrial ROS production, which induces stabilization of hypoxia-inducible factor-1α (HIF-1α) and consequently promotes glycolysis." https://t.co/6ySOYVgCcD https://t.co/ZGNRi4CquW @DrLBoominathan
2/3 Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis https://t.co/1mSDNl2v7m @RiceLaboratory @KannegantiLab, @KroganLab, @thechandalab, @Cambridge_COGUK https://t.co/mSTcmbgL93
RT @isa_picard: Une diète riche en sucre un facteur prédisposant a une moins bonne réponse immunitaire? L’influence negative d’une diète ri…
Une diète riche en sucre un facteur prédisposant a une moins bonne réponse immunitaire? L’influence negative d’une diète riche en sucre a déjà été observée sur la réponse immunitaire générale https://t.co/7RHj34Mmek et meme covid https://t.co/XKe6Cb4SvU et
@Jopo_dr Your thread is very interesting! Perhaps tangent to your thread: Could we be more endangered by a virus or bacteria that adapted to the rhythmic biological processes of a nocturnal reservoir? Thread: https://t.co/vhNV0wS9de https://t.co/3kObU9v
RT @WorldEdgeDG: I literally forgot the most important part, the reason I decided to write this lmao. https://t.co/iTehIls7TW
https://t.co/MZNAuJwALl "- Elevated glucose levels regulate viral replication and cytokine production in monocytes - Glycolysis sustains #SARSCoV2-induced monocyte response and viral replication - mtROS/HIF-1α is necessary for CoV-2 replication and monocy
@BroadwayVincenz @rmastersnest @TolstoyKarenina @ChanceTyColeman "Elevated Glucose Levels Favor SARS-CoV-2 Infection" - in the context of Covid eating habits certainly affect transmissibility. https://t.co/FmwtQHhxpB
RT @WorldEdgeDG: I literally forgot the most important part, the reason I decided to write this lmao. https://t.co/iTehIls7TW
@Canad_IANism @drmikehart @Sotacor Elevated Glucose Levels Favor SARS-CoV-2 Infection' - eating habits quite literally impact contagiousness in the context of covid. https://t.co/FmwtQHhxpB
RT @WorldEdgeDG: I literally forgot the most important part, the reason I decided to write this lmao. https://t.co/iTehIls7TW
RT @WorldEdgeDG: I literally forgot the most important part, the reason I decided to write this lmao. https://t.co/iTehIls7TW
RT @gutwat1: This isn’t takes about enough Limit your sugar intake.
RT @gutwat1: This isn’t takes about enough Limit your sugar intake.
RT @gutwat1: This isn’t takes about enough Limit your sugar intake.
RT @gutwat1: This isn’t takes about enough Limit your sugar intake.
RT @gutwat1: This isn’t takes about enough Limit your sugar intake.
RT @gutwat1: This isn’t takes about enough Limit your sugar intake.
RT @gutwat1: This isn’t takes about enough Limit your sugar intake.
RT @WorldEdgeDG: I literally forgot the most important part, the reason I decided to write this lmao. https://t.co/iTehIls7TW
RT @gutwat1: This isn’t takes about enough Limit your sugar intake.
RT @gutwat1: This isn’t takes about enough Limit your sugar intake. https://t.co/03KTJYmraa
RT @gutwat1: This isn’t takes about enough Limit your sugar intake.
高血糖な人がコロナハイリスクであること、何となく感じてた。 ただ、コロナ感染が高血糖に繋がるのは初耳。