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The Growth Inhibitory Potential and Antimetastatic Effect of Camel Urine on Breast Cancer Cells In Vitro and In Vivo

Overview of attention for article published in Integrative Cancer Therapies, June 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#22 of 864)
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

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1 policy source
twitter
81 X users
facebook
5 Facebook pages
reddit
1 Redditor
video
1 YouTube creator

Citations

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15 Dimensions

Readers on

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44 Mendeley
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Title
The Growth Inhibitory Potential and Antimetastatic Effect of Camel Urine on Breast Cancer Cells In Vitro and In Vivo
Published in
Integrative Cancer Therapies, June 2016
DOI 10.1177/1534735416656051
Pubmed ID
Authors

Firdaus Romli, Nadiah Abu, Faten A. Khorshid, Syed Umar Faruq Syed Najmuddin, Yeap Swee Keong, Nurul Elyani Mohamad, Muhajir Hamid, Noorjahan Banu Alitheen, Nik Mohd Afizan Nik Abd Rahman

Abstract

Although it may sound unpleasant, camel urine has been consumed extensively for years in the Middle East as it is believed to be able to treat a wide range of diseases such as fever, cold, or even cancer. People usually take it by mixing small drops with camel milk or take it directly. The project aims to study the effects of camel urine in inhibiting the growth potential and metastatic ability of 4T1 cancer cell line in vitro and in vivo. Based on the MTT result, the cytotoxicity of camel urine against 4T1 cell was established, and it was dose-dependent. Additionally, the antimetastatic potential of camel urine was tested by running several assays such as scratch assay, migration and invasion assay, and mouse aortic ring assay with promising results in the ability of camel urine to inhibit metastatic process of the 4T1 cells. In order to fully establish camel urine's potential, an in vivo study was carried out by treating mice inoculated with 4T1 cells with 2 different doses of camel urine. By the end of the treatment period, the tumor in both treated groups had reduced in size as compared to the control group. Additional assays such as the TUNEL assay, immunophenotyping, cytokine level detection assay, clonogenic assay, and proteome profiler demonstrated the capability of camel urine to reduce and inhibit the metastatic potential of 4T1 cells in vivo. To sum up, further study of anticancer properties of camel urine is justified, as evidenced through the in vitro and in vivo studies carried out. Better results were obtained at higher concentration of camel urine used in vivo. Apart from that, this project has laid out the mechanisms employed by the substance to inhibit the growth and the metastatic process of the 4T1 cell.

X Demographics

X Demographics

The data shown below were collected from the profiles of 81 X users who shared this research output. Click here to find out more about how the information was compiled.
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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 5 11%
Student > Master 4 9%
Lecturer 3 7%
Student > Bachelor 3 7%
Researcher 3 7%
Other 10 23%
Unknown 16 36%
Readers by discipline Count As %
Medicine and Dentistry 9 20%
Biochemistry, Genetics and Molecular Biology 5 11%
Agricultural and Biological Sciences 2 5%
Nursing and Health Professions 2 5%
Business, Management and Accounting 1 2%
Other 6 14%
Unknown 19 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 78. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2024.
All research outputs
#577,200
of 26,249,293 outputs
Outputs from Integrative Cancer Therapies
#22
of 864 outputs
Outputs of similar age
#11,135
of 371,369 outputs
Outputs of similar age from Integrative Cancer Therapies
#4
of 141 outputs
Altmetric has tracked 26,249,293 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 864 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.5. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 371,369 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 141 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.