It has been reported (https://t.co/1VsvYpGXRU) that liver metastasis restrains immunotherapy efficacy, we look forward to an ongoing trial from @_beam_On and U of M to see if ablation of liver metastases can improve immunotherapy responses, NCT05430009.
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Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination. 研究人员发现肝转移肿瘤能够改变肿瘤免疫微环境,将全身的CD8+T细胞“吸”到肝脏中,并让它们发生凋亡,遏制抗肿瘤免疫和免疫治疗的效果. https://t.co/rGA7jBSWdT
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@MathieuSpaas @JAMAOnc Also visceral metastases (eg, liver) seem to hinder the efficacy of immunotherapy: https://t.co/eGAi9F6K9U
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@Dreesenkl This paper might explain where I’m coming from…IO therapies have not been looked at in mss crc in patients w/o liver mets. Liver mets crush IO efficacy. So is bot/bal really differentiated or is trial just selecting for better patients? https://