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Population Epigenetics

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Attention for Chapter 266: Correcting for Sample Heterogeneity in Methylome-Wide Association Studies.
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Chapter title
Correcting for Sample Heterogeneity in Methylome-Wide Association Studies.
Chapter number 266
Book title
Population Epigenetics
Published in
Methods in molecular biology, August 2015
DOI 10.1007/7651_2015_266
Pubmed ID
Book ISBNs
978-1-4939-6901-2, 978-1-4939-6903-6
Authors

Zou, James Y, James Y. Zou, Zou, James Y.

Abstract

Epigenome-wide association studies (EWAS) face many of the same challenges as genome-wide association studies (GWAS), but have an added challenge in that the epigenome can vary dramatically across cell types. When cell-type composition differs between cases and controls, this leads to spurious associations that may obscure true associations. We have developed a computational method, FaST-LMM-EWASher, which automatically corrects for cell-type composition without needing explicit knowledge of it. In this chapter, we provide a tutorial on using FaST-LMM-EWASher for DNA methylation data and discuss data analysis strategies.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 31%
Student > Ph. D. Student 2 15%
Unspecified 1 8%
Student > Bachelor 1 8%
Student > Master 1 8%
Other 0 0%
Unknown 4 31%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 15%
Agricultural and Biological Sciences 2 15%
Computer Science 2 15%
Nursing and Health Professions 1 8%
Unspecified 1 8%
Other 1 8%
Unknown 4 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2015.
All research outputs
#18,422,065
of 22,821,814 outputs
Outputs from Methods in molecular biology
#7,917
of 13,124 outputs
Outputs of similar age
#189,905
of 264,036 outputs
Outputs of similar age from Methods in molecular biology
#11
of 18 outputs
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So far Altmetric has tracked 13,124 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.