Chapter title |
Analysis of Imprinted Gene Regulation.
|
---|---|
Chapter number | 264 |
Book title |
Population Epigenetics
|
Published in |
Methods in molecular biology, November 2015
|
DOI | 10.1007/7651_2015_264 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6901-2, 978-1-4939-6903-6
|
Authors |
Skaar, David A, Jirtle, Randy L, David A. Skaar, Randy L. Jirtle, Skaar, David A., Jirtle, Randy L. |
Abstract |
Genetic studies have been well established for identifying sequence variants associated with phenotypes. With the expanding field of epigenetics, and the growing understanding of epigenetic regulation of gene expression, similar studies can be undertaken to also define associations between epigenetic variation and phenotypes. Of particular interest are imprinted genes, which have parent-of-origin specific regulation and expression, and are key regulators of early development. Herein, we describe methods for examining epigenetic regulation by the two major hallmarks of imprinted genes: differentially methylated regions (DMRs), regulatory DNA sequences with allele specific methylation; and monoallelic expression, the silencing and transcription of opposite alleles in a parent-of-origin specific manner. |
X Demographics
Geographical breakdown
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Venezuela, Bolivarian Republic of | 1 | 33% |
France | 1 | 33% |
United States | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 3 | 27% |
Researcher | 2 | 18% |
Student > Bachelor | 2 | 18% |
Student > Ph. D. Student | 2 | 18% |
Unspecified | 1 | 9% |
Other | 1 | 9% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 4 | 36% |
Agricultural and Biological Sciences | 3 | 27% |
Nursing and Health Professions | 1 | 9% |
Psychology | 1 | 9% |
Social Sciences | 1 | 9% |
Other | 1 | 9% |