Chapter title |
Clonal Evolution of Stem Cells in the Gastrointestinal Tract.
|
---|---|
Chapter number | 2 |
Book title |
Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract
|
Published in |
Advances in experimental medicine and biology, August 2016
|
DOI | 10.1007/978-3-319-41388-4_2 |
Pubmed ID | |
Book ISBNs |
978-3-31-941386-0, 978-3-31-941388-4
|
Authors |
Juergen Fink, Bon-Kyoung Koo, Fink, Juergen, Koo, Bon-Kyoung |
Editors |
Marnix Jansen, Nicholas A. Wright |
Abstract |
The field of gastrointestinal epithelial stem cells is a rapidly developing area of adult stem cell research. The discovery of Lgr5(+) intestinal stem cells has enabled us to study many hidden aspects of the biology of gastrointestinal adult stem cells. Marked by Lgr5 and Troy, several novel endodermal stem cells have been identified in the gastrointestinal tract. A precise working model of stem cell propagation, dynamics, and plasticity has been revealed by a genetic labeling method, termed lineage tracing. This chapter introduces the reidentification of crypt base columnar cells as Lgr5(+) stem cells in the intestine. Subsequently, it will discuss dynamic clonal evolution and cellular plasticity in the intestinal stem cell zone, as well as in stem cell zones of stomach glands. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 30% |
Student > Master | 2 | 10% |
Researcher | 2 | 10% |
Lecturer | 1 | 5% |
Other | 1 | 5% |
Other | 1 | 5% |
Unknown | 7 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 4 | 20% |
Biochemistry, Genetics and Molecular Biology | 3 | 15% |
Chemical Engineering | 2 | 10% |
Immunology and Microbiology | 1 | 5% |
Medicine and Dentistry | 1 | 5% |
Other | 1 | 5% |
Unknown | 8 | 40% |