Chapter title |
Regulation of Interleukin-10 Expression
|
---|---|
Chapter number | 5 |
Book title |
Regulation of Cytokine Gene Expression in Immunity and Diseases
|
Published in |
Advances in experimental medicine and biology, October 2016
|
DOI | 10.1007/978-94-024-0921-5_5 |
Pubmed ID | |
Book ISBNs |
978-9-40-240919-2, 978-9-40-240921-5
|
Authors |
Sascha Rutz, Wenjun Ouyang |
Editors |
Xiaojing Ma |
Abstract |
Interleukin (IL)-10 is an essential anti-inflammatory cytokine that plays important roles as a negative regulator of immune responses to microbial antigens. Loss of IL-10 results in the spontaneous development of inflammatory bowel disease as a consequence of an excessive immune response to the gut microbiota. IL-10 also functions to prevent excessive inflammation during the course of infection. IL-10 can be produced in response to pro-inflammatory signals by virtually all immune cells, including T cells, B cells, macrophages, and dendritic cells. Given its function in maintaining the delicate balance between effective immunity and tissue protection, it is evident that IL-10 expression is highly dynamic and needs to be tightly regulated. The transcriptional regulation of IL-10 production in myeloid cells and T cells is the topic of this review. Drivers of IL-10 expression as well as their downstream signaling pathways and transcription factors will be discussed. We will examine in more detail how various signals in CD4(+) T cells converge on common transcriptional circuits, which fine-tune IL-10 expression in a context-dependent manner. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 136 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 13% |
Student > Bachelor | 16 | 12% |
Student > Master | 15 | 11% |
Researcher | 10 | 7% |
Student > Doctoral Student | 6 | 4% |
Other | 11 | 8% |
Unknown | 61 | 45% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 19 | 14% |
Medicine and Dentistry | 18 | 13% |
Immunology and Microbiology | 12 | 9% |
Agricultural and Biological Sciences | 7 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
Other | 10 | 7% |
Unknown | 66 | 49% |