Chapter title |
The Immunobiology of Interleukin-35 and Its Regulation and Gene Expression.
|
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Chapter number | 10 |
Book title |
Regulation of Cytokine Gene Expression in Immunity and Diseases
|
Published in |
Advances in experimental medicine and biology, October 2016
|
DOI | 10.1007/978-94-024-0921-5_10 |
Pubmed ID | |
Book ISBNs |
978-9-40-240919-2, 978-9-40-240921-5
|
Authors |
Mei Song, Xiaojing Ma |
Editors |
Xiaojing Ma |
Abstract |
Interleukin-35 (IL-35) is the latest addition to the IL-12 family of heterodimeric cytokines, consisting of IL-12 p35 subunit and IL-27β subunit Epstein-Barr virus induced 3 (EBI3). Since its discovery, IL-35 has been shown to exhibit immunosuppressive activities which are distinct from other members of IL-12 family. IL-35 is also unique in that it is expressed primarily by regulatory T-cells (Tregs) rather than by antigen-presenting cells (APCs). IL-35 can directly suppress effector T-cell proliferation and function and inhibit the differentiation of Th17 cells. It is also able to expand regulatory responses to promote tolerance to infections by generating a potent population of IL-35-producing inducible Tregs (iTr35). As the new cellular sources of IL-35 such as CD8(+)Tregs, Bregs, and tolerogenic dendritic cells DCs (tolDCs) are identified, more immunoregulatory functions of this cytokine are explored. IL-35 has been shown to be associated with a range of autoimmune diseases and cancer models. It appears to be a promising diagnostic biomarker. A greater understanding of the expression and regulatory mechanisms of IL-35 will be beneficial to the development of novel immune therapies. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 35 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 14% |
Researcher | 4 | 11% |
Student > Postgraduate | 4 | 11% |
Professor | 4 | 11% |
Student > Doctoral Student | 3 | 9% |
Other | 3 | 9% |
Unknown | 12 | 34% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 6 | 17% |
Immunology and Microbiology | 4 | 11% |
Agricultural and Biological Sciences | 4 | 11% |
Biochemistry, Genetics and Molecular Biology | 3 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Other | 1 | 3% |
Unknown | 15 | 43% |