Chapter title |
Regulation of Interleukin-23 Expression in Health and Disease.
|
---|---|
Chapter number | 8 |
Book title |
Regulation of Cytokine Gene Expression in Immunity and Diseases
|
Published in |
Advances in experimental medicine and biology, October 2016
|
DOI | 10.1007/978-94-024-0921-5_8 |
Pubmed ID | |
Book ISBNs |
978-9-40-240919-2, 978-9-40-240921-5
|
Authors |
Iain Welsby, Stanislas Goriely, Welsby, Iain, Goriely, Stanislas |
Editors |
Xiaojing Ma |
Abstract |
Interleukin (IL)-23 plays a central role in the orchestration of inflammatory responses. Produced by dendritic cells and macrophages, this cytokine promotes the protection of the host against mucosal pathogens through the induction of IL-17 and related cytokines by lymphoid cells. Preclinical disease models and association studies in humans have also clearly demonstrated the implication of IL-23 signalling pathway in inflammatory diseases. Indeed, this cytokine is now considered as a major therapeutic target in immune-based pathologies such as psoriasis, ankylosing spondylitis or Crohn's disease. Furthermore, in the context of inflammation-related cancer, IL-23 is thought to contribute to tumorigenesis and progression to metastatic disease. Herein, we review our current understanding of IL-23 regulation at the transcriptional and post-transcriptional levels. We discuss the relevance of these findings in the context of infection, chronic inflammation and cancer. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 20% |
Student > Master | 5 | 17% |
Other | 3 | 10% |
Researcher | 3 | 10% |
Lecturer | 2 | 7% |
Other | 5 | 17% |
Unknown | 6 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 30% |
Immunology and Microbiology | 4 | 13% |
Agricultural and Biological Sciences | 4 | 13% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 3 | 10% |
Unknown | 7 | 23% |