Chapter title |
Multiple Sequence Alignment.
|
---|---|
Chapter number | 8 |
Book title |
Bioinformatics
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-6622-6_8 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6620-2, 978-1-4939-6622-6
|
Authors |
Punto Bawono, Maurits Dijkstra, Walter Pirovano, Anton Feenstra, Sanne Abeln, Jaap Heringa, Bawono, Punto, Dijkstra, Maurits, Pirovano, Walter, Feenstra, Anton, Abeln, Sanne, Heringa, Jaap |
Editors |
Jonathan M. Keith |
Abstract |
The increasing importance of Next Generation Sequencing (NGS) techniques has highlighted the key role of multiple sequence alignment (MSA) in comparative structure and function analysis of biological sequences. MSA often leads to fundamental biological insight into sequence-structure-function relationships of nucleotide or protein sequence families. Significant advances have been achieved in this field, and many useful tools have been developed for constructing alignments, although many biological and methodological issues are still open. This chapter first provides some background information and considerations associated with MSA techniques, concentrating on the alignment of protein sequences. Then, a practical overview of currently available methods and a description of their specific advantages and limitations are given, to serve as a helpful guide or starting point for researchers who aim to construct a reliable MSA. |
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Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 42 | 21% |
Student > Ph. D. Student | 25 | 12% |
Researcher | 25 | 12% |
Student > Master | 25 | 12% |
Other | 7 | 3% |
Other | 26 | 13% |
Unknown | 51 | 25% |
Readers by discipline | Count | As % |
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Computer Science | 16 | 8% |
Immunology and Microbiology | 7 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 3% |
Other | 21 | 10% |
Unknown | 54 | 27% |