Chapter title |
Alternative Cell Sources to Adult Hepatocytes for Hepatic Cell Therapy
|
---|---|
Chapter number | 2 |
Book title |
Hepatocyte Transplantation
|
Published in |
Methods in molecular biology, November 2016
|
DOI | 10.1007/978-1-4939-6506-9_2 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6504-5, 978-1-4939-6506-9
|
Authors |
Eugenia Pareja, María José Gómez-Lechón, Laia Tolosa |
Editors |
Peggy Stock, Bruno Christ |
Abstract |
Adult hepatocyte transplantation is limited by scarce availability of suitable donor liver tissue for hepatocyte isolation. New cell-based therapies are being developed to supplement whole-organ liver transplantation, to reduce the waiting-list mortality rate, and to obtain more sustained and significant metabolic correction. Fetal livers and unsuitable neonatal livers for organ transplantation have been proposed as potential useful sources of hepatic cells for cell therapy. However, the major challenge is to use alternative cell sources for transplantation that can be derived from reproducible methods. Different types of stem cells with hepatic differentiation potential are eligible for generating large numbers of functional hepatocytes for liver cell therapy to treat degenerative disorders, inborn hepatic metabolic diseases, and organ failure. Clinical trials are designed to fully establish the safety profile of such therapies and to define target patient groups and standardized protocols. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 5 | 22% |
Other | 3 | 13% |
Professor > Associate Professor | 2 | 9% |
Researcher | 2 | 9% |
Student > Ph. D. Student | 1 | 4% |
Other | 2 | 9% |
Unknown | 8 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 30% |
Biochemistry, Genetics and Molecular Biology | 3 | 13% |
Agricultural and Biological Sciences | 2 | 9% |
Nursing and Health Professions | 1 | 4% |
Unknown | 10 | 43% |