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Hepatocyte Transplantation

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Cover of 'Hepatocyte Transplantation'

Table of Contents

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    Book Overview
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    Chapter 1 Hepatocyte Transplantation in Special Populations: Clinical Use in Children
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    Chapter 2 Alternative Cell Sources to Adult Hepatocytes for Hepatic Cell Therapy
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    Chapter 3 Late Gestation Fetal Hepatocytes for Liver Repopulation in the Rat
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    Chapter 4 A Modified Protocol for the Isolation of Primary Human Hepatocytes with Improved Viability and Function from Normal and Diseased Human Liver
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    Chapter 5 Thy-1 (CD90)-Positive Hepatic Progenitor Cells, Hepatoctyes, and Non-parenchymal Liver Cells Isolated from Human Livers
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    Chapter 6 Propagation of Human Hepatocytes in uPA/SCID Mice: Producing Chimeric Mice with Humanized Liver
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    Chapter 7 Fetal Liver Stem/Progenitor Cell Transplantation: A Model to Study Tissue Mass Replacement and Cell-Based Therapies
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    Chapter 8 Successful Engraftment of Human Hepatocytes in uPA-SCID and FRG® KO Mice
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    Chapter 9 Gunn Rats as a Surrogate Model for Evaluation of Hepatocyte Transplantation-Based Therapies of Crigler–Najjar Syndrome Type 1
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    Chapter 10 Experimental Hepatocyte Transplantation in Pigs
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    Chapter 11 Demonstrating Potential of Cell Therapy for Wilson’s Disease with the Long-Evans Cinnamon Rat Model
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    Chapter 12 Use of Thymidine Kinase Recombinant Adenovirus and Ganciclovir Mediated Mouse Liver Preconditioning for Hepatocyte Xenotransplantation
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    Chapter 13 Minimally Invasive Liver Preconditioning for Hepatocyte Transplantation in Rats
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    Chapter 14 Preclinical Swine Models for Monitoring of Hepatocyte Transplantation by MRI
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    Chapter 15 Deep Digging: Far Red Imaging for the Monitoring of Transplanted Hepatocytes in Rats
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    Chapter 16 Isolation of GMP Grade Human Hepatocytes from Remnant Liver Tissue of Living Donor Liver Transplantation
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    Chapter 17 Isolation of Hepatocytes and Stellate Cells from a Single Piece of Human Liver
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    Chapter 18 Microencapsulation of Hepatocytes and Mesenchymal Stem Cells for Therapeutic Applications
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    Chapter 19 Alginate Encapsulation of Human Hepatocytes and Assessment of Microbeads
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    Chapter 20 Report on Liver Cell Transplantation Using Human Fetal Liver Cells
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    Chapter 21 Hepatocyte Transplantation in Children
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    Chapter 22 Creation of Three-Dimensional Liver Tissue Models from Experimental Images for Systems Medicine
Attention for Chapter 22: Creation of Three-Dimensional Liver Tissue Models from Experimental Images for Systems Medicine
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Chapter title
Creation of Three-Dimensional Liver Tissue Models from Experimental Images for Systems Medicine
Chapter number 22
Book title
Hepatocyte Transplantation
Published in
Methods in molecular biology, November 2016
DOI 10.1007/978-1-4939-6506-9_22
Pubmed ID
Book ISBNs
978-1-4939-6504-5, 978-1-4939-6506-9
Authors

Stefan Hoehme, Adrian Friebel, Seddik Hammad, Dirk Drasdo, Jan G. Hengstler

Editors

Peggy Stock, Bruno Christ

Abstract

In this chapter, we illustrate how three-dimensional liver tissue models can be created from experimental image modalities by utilizing a well-established processing chain of experiments, microscopic imaging, image processing, image analysis and model construction. We describe how key features of liver tissue architecture are quantified and translated into model parameterizations, and show how a systematic iteration of experiments and model simulations often leads to a better understanding of biological phenomena in systems biology and systems medicine.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 20%
Student > Postgraduate 2 20%
Student > Bachelor 1 10%
Lecturer 1 10%
Professor > Associate Professor 1 10%
Other 1 10%
Unknown 2 20%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 2 20%
Biochemistry, Genetics and Molecular Biology 1 10%
Immunology and Microbiology 1 10%
Physics and Astronomy 1 10%
Engineering 1 10%
Other 0 0%
Unknown 4 40%