| Chapter title |
Gut Hormone Regulation and Secretion via FFA1 and FFA4
|
|---|---|
| Chapter number | 46 |
| Book title |
Free Fatty Acid Receptors
|
| Published in |
Handbook of experimental pharmacology, November 2016
|
| DOI | 10.1007/164_2016_46 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-950692-0, 978-3-31-950693-7
|
| Authors |
Gribble, Fiona M, Diakogiannaki, Eleftheria, Reimann, Frank, Fiona M. Gribble, Eleftheria Diakogiannaki, Frank Reimann, Gribble, Fiona M. |
| Editors |
Graeme Milligan, Ikuo Kimura |
| Abstract |
The digestion, absorption and utilisation of dietary triglycerides are controlled by gut hormones, released from enteroendocrine cells along the length of the gastrointestinal tract. Major players in the detection of ingested lipids are the free fatty acid receptors FFA1 and FFA4, which are highly expressed on enteroendocrine cells. These receptors are activated when free fatty acids (FFA) are absorbed across the intestinal epithelium, and provide a dynamic hormonal signal indicating that lipids are arriving in the bloodstream from the gut. This review addresses our current knowledge of how ingested triglycerides modulate gut hormone release via FFA1 and FFA4. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 20% |
| Student > Doctoral Student | 3 | 10% |
| Student > Master | 3 | 10% |
| Professor > Associate Professor | 3 | 10% |
| Researcher | 3 | 10% |
| Other | 3 | 10% |
| Unknown | 9 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 17% |
| Agricultural and Biological Sciences | 4 | 13% |
| Medicine and Dentistry | 4 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 10% |
| Chemistry | 2 | 7% |
| Other | 3 | 10% |
| Unknown | 9 | 30% |