| Chapter title |
Imaging MS of Rodent Ocular Tissues and the Optic Nerve
|
|---|---|
| Chapter number | 3 |
| Book title |
Imaging Mass Spectrometry
|
| Published in |
Methods in molecular biology, May 2017
|
| DOI | 10.1007/978-1-4939-7051-3_3 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-7050-6, 978-1-4939-7051-3
|
| Authors |
David M. G. Anderson, Wendi Lambert, David J. Calkins, Zsolt Ablonczy, Rosalie K. Crouch, Richard M. Caprioli, Kevin L. Schey |
| Editors |
Laura M. Cole |
| Abstract |
The visual system is comprised of many specialized cell types that are essential for relaying sensory information about an animal's surroundings to the brain. The cells present in ocular tissue are notoriously delicate, making it particularly challenging to section thin slices of unfixed tissue. Maintaining the morphology of the native tissue is crucial for accurate observations by either conventional staining techniques or in this instance matrix-assisted laser desorption ionization (MALDI IMS) or imaging using mass spectrometry. As vision loss is a significantly debilitating condition, studying molecular mechanisms involved in the process of vision loss is a critically important area of research. |
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Mendeley readers
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