| Chapter title |
Contribution of Impulsivity and Serotonin Receptor Neuroadaptations to the Development of an MDMA (‘Ecstasy’) Substance Use Disorder
|
|---|---|
| Chapter number | 421 |
| Book title |
Non-medical and illicit use of psychoactive drugs
|
| Published in |
Current topics in behavioral neurosciences, December 2015
|
| DOI | 10.1007/7854_2015_421 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-960014-7, 978-3-31-960016-1
|
| Authors |
Schenk, Susan, Aronsen, Dane, Susan Schenk, Dane Aronsen |
| Abstract |
As is the case with other drugs of abuse, a proportion of ecstasy users develop symptoms consistent with a substance use disorder (SUD). In this paper, we propose that the pharmacology of MDMA, the primary psychoactive component of ecstasy tablets, changes markedly with repeated exposure and that neuroadaptations in dopamine and serotonin brain systems underlie the shift from MDMA use to MDMA misuse in susceptible subjects. Data from both the human and laboratory animal literature are synthesized to support the idea that (1) MDMA becomes a less efficacious serotonin releaser and a more efficacious dopamine releaser with the development of behaviour consistent with an SUD and (2) that upregulated serotonin receptor mechanisms contribute to the development of the MDMA SUD via dysregulated inhibitory control associated with the trait of impulsivity. |
X Demographics
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|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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|---|---|---|
| Unknown | 21 | 100% |
Demographic breakdown
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|---|---|---|
| Student > Bachelor | 4 | 19% |
| Student > Ph. D. Student | 3 | 14% |
| Professor > Associate Professor | 2 | 10% |
| Researcher | 2 | 10% |
| Student > Doctoral Student | 1 | 5% |
| Other | 2 | 10% |
| Unknown | 7 | 33% |
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|---|---|---|
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| Psychology | 3 | 14% |
| Agricultural and Biological Sciences | 2 | 10% |
| Nursing and Health Professions | 1 | 5% |
| Environmental Science | 1 | 5% |
| Other | 2 | 10% |
| Unknown | 9 | 43% |