Chapter title |
The Abuse Potential of Prescription Opioids in Humans—Closing in on the First Century of Research
|
---|---|
Chapter number | 448 |
Book title |
Non-medical and illicit use of psychoactive drugs
|
Published in |
Current topics in behavioral neurosciences, January 2016
|
DOI | 10.1007/7854_2016_448 |
Pubmed ID | |
Book ISBNs |
978-3-31-960014-7, 978-3-31-960016-1
|
Authors |
Sharon L. Walsh, Shanna Babalonis, Walsh, Sharon L., Babalonis, Shanna |
Abstract |
While opioids are very effective analgesics for treating acute pain, humans have struggled with opiate addiction for millenia. An opium abuse epidemic in the early 1900's led the US government to develop a systematic research infrastructure and scientific plan to produce new compounds with analgesic properties but without abuse liability. This review describes the techniques that were developed for testing in the human laboratory, including empirically derived outcome measures and required elements for human abuse potential assessment. The evaluation and characterization of semi-synthetic and synthetic opioids, including full mu opioid agonists, partial agonists and mixed agonist-antagonists, are described across several decades of research. Finally, the prescription opioid epidemic beginning in the 1990's in the US led to a resurgence in abuse potential evaluations, and the application of these methods to the study of novel abuse-deterrent formulations is discussed. |
X Demographics
Geographical breakdown
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Nigeria | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Doctoral Student | 4 | 20% |
Student > Bachelor | 2 | 10% |
Student > Ph. D. Student | 2 | 10% |
Student > Master | 2 | 10% |
Professor | 1 | 5% |
Other | 3 | 15% |
Unknown | 6 | 30% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 5 | 25% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 15% |
Psychology | 3 | 15% |
Neuroscience | 2 | 10% |
Nursing and Health Professions | 1 | 5% |
Other | 0 | 0% |
Unknown | 6 | 30% |