| Chapter title |
Epithelial Barrier Function in Gut-Bone Signaling
|
|---|---|
| Chapter number | 8 |
| Book title |
Understanding the Gut-Bone Signaling Axis
|
| Published in |
Advances in experimental medicine and biology, November 2017
|
| DOI | 10.1007/978-3-319-66653-2_8 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-966651-8, 978-3-31-966653-2
|
| Authors |
Naiomy Deliz Rios-Arce, Fraser L. Collins, Jonathan D. Schepper, Michael D. Steury, Sandi Raehtz, Heather Mallin, Danny T. Schoenherr, Narayanan Parameswaran, Laura R. McCabe |
| Abstract |
The intestinal epithelial barrier plays an essential role in maintaining host homeostasis. The barrier regulates nutrient absorption as well as prevents the invasion of pathogenic bacteria in the host. It is composed of epithelial cells, tight junctions, and a mucus layer. Several factors, such as cytokines, diet, and diseases, can affect this barrier. These factors have been shown to increase intestinal permeability, inflammation, and translocation of pathogenic bacteria. In addition, dysregulation of the epithelial barrier can result in inflammatory diseases such as inflammatory bowel disease. Our lab and others have also shown that barrier disruption can have systemic effects including bone loss. In this chapter, we will discuss the current literature to understand the link between intestinal barrier and bone. We will discuss how inflammation, aging, dysbiosis, and metabolic diseases can affect intestinal barrier-bone link. In addition, we will highlight the current suggested mechanism between intestinal barrier and bone. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 75 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 15% |
| Student > Bachelor | 11 | 15% |
| Student > Master | 7 | 9% |
| Student > Doctoral Student | 5 | 7% |
| Professor | 3 | 4% |
| Other | 7 | 9% |
| Unknown | 31 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 12% |
| Biochemistry, Genetics and Molecular Biology | 9 | 12% |
| Medicine and Dentistry | 5 | 7% |
| Immunology and Microbiology | 4 | 5% |
| Chemical Engineering | 3 | 4% |
| Other | 10 | 13% |
| Unknown | 35 | 47% |