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Mendeley readers
| Chapter title |
Clinical Usefulness of the Histoculture Drug Response Assay for Prostate Cancer and Benign Prostate Hypertrophy (BPH)
|
|---|---|
| Chapter number | 11 |
| Book title |
3D Sponge-Matrix Histoculture
|
| Published in |
Methods in molecular biology, January 2018
|
| DOI | 10.1007/978-1-4939-7745-1_11 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-7743-7, 978-1-4939-7745-1
|
| Authors |
Robert M. Hoffman |
| Abstract |
The histoculture drug response assay (HDRA) has been adapted to determine androgen sensitivity in Gelfoam histoculture of human benign prostatic tissue as well as prostate cancer. Gelfoam histoculture was used to measure androgen-independent and androgen-dependent growth of benign and malignant prostate tissue. The androgen-sensitivity index was significantly higher in 23 paired specimens of prostate cancer compared to benign prostate hypertrophy (BPH). Genistein decreased the androgen-sensitivity index of BPH and prostate cancer in Gelfoam® histoculture in a dose-dependent manner. |
Mendeley readers
The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 6 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 50% |
| Lecturer | 1 | 17% |
| Researcher | 1 | 17% |
| Unknown | 1 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 1 | 17% |
| Computer Science | 1 | 17% |
| Medicine and Dentistry | 1 | 17% |
| Materials Science | 1 | 17% |
| Design | 1 | 17% |
| Other | 0 | 0% |
| Unknown | 1 | 17% |