Chapter title |
Hippo Signaling in Mitosis: An Updated View in Light of the MEN Pathway
|
---|---|
Chapter number | 19 |
Book title |
The Mitotic Exit Network
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-6502-1_19 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6500-7, 978-1-4939-6502-1
|
Authors |
Alexander Hergovich, Hergovich, Alexander |
Abstract |
The Hippo pathway is an essential tumor suppressor signaling network that coordinates cell proliferation, death, and differentiation in higher eukaryotes. Intriguingly, the core components of the Hippo pathway are conserved from yeast to man, with the yeast analogs of mammalian MST1/2 (fly Hippo), MOB1 (fly Mats), LATS1/2 (fly Warts), and NDR1/2 (fly Tricornered) functioning as essential components of the mitotic exit network (MEN). Here, we update our previous summary of mitotic functions of Hippo core components in Drosophila melanogaster and mammals, with particular emphasis on similarities between the yeast MEN pathway and mitotic Hippo signaling. Mitotic functions of YAP and TAZ, the two main effectors of Hippo signaling, are also discussed. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 4 | 29% |
Researcher | 2 | 14% |
Student > Doctoral Student | 1 | 7% |
Other | 1 | 7% |
Student > Bachelor | 1 | 7% |
Other | 1 | 7% |
Unknown | 4 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 5 | 36% |
Biochemistry, Genetics and Molecular Biology | 3 | 21% |
Environmental Science | 1 | 7% |
Medicine and Dentistry | 1 | 7% |
Unknown | 4 | 29% |