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Mammalian Transient Receptor Potential (TRP) Cation Channels

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Cover of 'Mammalian Transient Receptor Potential (TRP) Cation Channels'

Table of Contents

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    Book Overview
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    Chapter 1 TRP Channels and Thermosensation
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    Chapter 2 TRPs in Mechanosensing and Volume Regulation
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    Chapter 3 TRPs as Chemosensors (ROS, RNS, RCS, Gasotransmitters)
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    Chapter 4 Photosensitive TRPs.
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    Chapter 5 TRPs in Taste and Chemesthesis
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    Chapter 6 TRPs and Pain.
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    Chapter 7 TRPs in Hearing.
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    Chapter 8 TRPs in Olfaction
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    Chapter 9 Evolutionarily Conserved, Multitasking TRP Channels: Lessons from Worms and Flies
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    Chapter 10 Structural Biology of TRP Channels
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    Chapter 11 High-Resolution Views of TRPV1 and Their Implications for the TRP Channel Superfamily
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    Chapter 12 Physiological Functions and Regulation of TRPC Channels
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    Chapter 13 The TRPCs–STIM1–Orai Interaction
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    Chapter 14 The TRPC Family of TRP Channels: Roles Inferred (Mostly) from Knockout Mice and Relationship to ORAI Proteins
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    Chapter 15 TRPs: Modulation by Drug-Like Compounds
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    Chapter 16 TRP Channels in Reproductive (Neuro)Endocrinology
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    Chapter 17 Modulation of TRP Ion Channels by Venomous Toxins
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    Chapter 18 Phosphoinositide Regulation of TRP Channels
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    Chapter 19 TRP Modulation by Natural Compounds
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    Chapter 20 What Do We Really Know and What Do We Need to Know: Some Controversies, Perspectives, and Surprises
Attention for Chapter 4: Photosensitive TRPs.
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Chapter title
Photosensitive TRPs.
Chapter number 4
Book title
Mammalian Transient Receptor Potential (TRP) Cation Channels
Published in
Handbook of experimental pharmacology, April 2014
DOI 10.1007/978-3-319-05161-1_4
Pubmed ID
Book ISBNs
978-3-31-905160-4, 978-3-31-905161-1

Roger C Hardie, Hardie RC, Hardie, Roger C., Roger C. Hardie


The Drosophila "transient receptor potential" channel is the prototypical TRP channel, belonging to and defining the TRPC subfamily. Together with a second TRPC channel, trp-like (TRPL), TRP mediates the transducer current in the fly's photoreceptors. TRP and TRPL are also implicated in olfaction and Malpighian tubule function. In photoreceptors, TRP and TRPL are localised in the ~30,000 packed microvilli that form the photosensitive "rhabdomere"-a light-guiding rod, housing rhodopsin and the rest of the phototransduction machinery. TRP (but not TRPL) is assembled into multimolecular signalling complexes by a PDZ-domain scaffolding protein (INAD). TRPL (but not TRP) undergoes light-regulated translocation between cell body and rhabdomere. TRP and TRPL are also found in photoreceptor synapses where they may play a role in synaptic transmission. Like other TRPC channels, TRP and TRPL are activated by a G protein-coupled phospholipase C (PLCβ4) cascade. Although still debated, recent evidence indicates the channels can be activated by a combination of PIP2 depletion and protons released by the PLC reaction. PIP2 depletion may act mechanically as membrane area is reduced by cleavage of PIP2's bulky inositol headgroup. TRP, which dominates the light-sensitive current, is Ca(2+) selective (P Ca:P Cs >50:1), whilst TRPL has a modest Ca(2+) permeability (P Ca:P Cs ~5:1). Ca(2+) influx via the channels has profound positive and negative feedback roles, required for the rapid response kinetics, with Ca(2+) rapidly facilitating TRP (but not TRPL) and also inhibiting both channels. In trp mutants, stimulation by light results in rapid depletion of microvillar PIP2 due to lack of Ca(2+) influx required to inhibit PLC. This accounts for the "transient receptor potential" phenotype that gives the family its name and, over a period of days, leads to light-dependent retinal degeneration. Gain-of-function trp mutants with uncontrolled Ca(2+) influx also undergo retinal degeneration due to Ca(2+) cytotoxicity. In vertebrate retina, mice knockout studies suggest that TRPC6 and TRPC7 mediate a PLCβ4-activated transducer current in intrinsically photosensitive retinal ganglion cells, expressing melanopsin. TRPA1 has been implicated as a "photo-sensing" TRP channel in human melanocytes and light-sensitive neurons in the body wall of Drosophila.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 22%
Student > Ph. D. Student 4 15%
Student > Bachelor 3 11%
Student > Postgraduate 2 7%
Professor > Associate Professor 2 7%
Other 5 19%
Unknown 5 19%
Readers by discipline Count As %
Neuroscience 6 22%
Medicine and Dentistry 5 19%
Agricultural and Biological Sciences 3 11%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Biochemistry, Genetics and Molecular Biology 2 7%
Other 3 11%
Unknown 6 22%