| Chapter title |
TRPs and Pain.
|
|---|---|
| Chapter number | 6 |
| Book title |
Mammalian Transient Receptor Potential (TRP) Cation Channels
|
| Published in |
Handbook of experimental pharmacology, June 2014
|
| DOI | 10.1007/978-3-319-05161-1_6 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-905160-4, 978-3-31-905161-1
|
| Authors |
Sexton JE, Vernon J, Wood JN, Jane E. Sexton, Jeffrey Vernon, John N. Wood, Sexton, Jane E., Vernon, Jeffrey, Wood, John N. |
| Abstract |
Pain usually occurs as a result of tissue damage and has a role in healing and protection. However, in certain conditions it has no functional purpose and can become chronic and debilitating. A demand for more effective treatments to deal with this highly prevalent problem requires a better understanding of the underlying mechanisms. TRP channels are associated with numerous sensory functions across a wide range of species. Investigation into the expression patterns, electrophysiological properties and the effects of channel deletion in transgenic animal models have produced a great deal of evidence linking these channels to transduction of noxious stimuli as well as signalling within the pain system. |
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Mendeley readers
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