TRPs and Pain.
Mammalian Transient Receptor Potential (TRP) Cation Channels
Handbook of experimental pharmacology, June 2014
Sexton JE, Vernon J, Wood JN, Jane E. Sexton, Jeffrey Vernon, John N. Wood
Pain usually occurs as a result of tissue damage and has a role in healing and protection. However, in certain conditions it has no functional purpose and can become chronic and debilitating. A demand for more effective treatments to deal with this highly prevalent problem requires a better understanding of the underlying mechanisms. TRP channels are associated with numerous sensory functions across a wide range of species. Investigation into the expression patterns, electrophysiological properties and the effects of channel deletion in transgenic animal models have produced a great deal of evidence linking these channels to transduction of noxious stimuli as well as signalling within the pain system.
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