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Protein Amyloid Aggregation

Overview of attention for book
Cover of 'Protein Amyloid Aggregation'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein.
  3. Altmetric Badge
    Chapter 2 Isotope-Labeled Amyloids via Synthesis, Expression, and Chemical Ligation for Use in FTIR, 2D IR, and NMR Studies.
  4. Altmetric Badge
    Chapter 3 Intermolecular Paramagnetic Relaxation Enhancement (PRE) Studies of Transient Complexes in Intrinsically Disordered Proteins.
  5. Altmetric Badge
    Chapter 4 Detection of Helical Intermediates During Amyloid Formation by Intrinsically Disordered Polypeptides and Proteins.
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    Chapter 5 Fluorescence Correlation Spectroscopy: A Tool to Study Protein Oligomerization and Aggregation In Vitro and In Vivo.
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    Chapter 6 Deep UV Resonance Raman Spectroscopy for Characterizing Amyloid Aggregation
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    Chapter 7 Analyzing Tau Aggregation with Electron Microscopy.
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    Chapter 8 Characterization of Amyloid Oligomers by Electrospray Ionization-Ion Mobility Spectrometry-Mass Spectrometry (ESI-IMS-MS).
  10. Altmetric Badge
    Chapter 9 Formation and Characterization of α-Synuclein Oligomers.
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    Chapter 10 Fluorescence Methods for Unraveling Oligomeric Amyloid Intermediates
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    Chapter 11 Preparation of Amyloid Fibrils for Magic-Angle Spinning Solid-State NMR Spectroscopy
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    Chapter 12 Spin Labeling and Characterization of Tau Fibrils Using Electron Paramagnetic Resonance (EPR).
  14. Altmetric Badge
    Chapter 13 Preparation of Crystalline Samples of Amyloid Fibrils and Oligomers
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    Chapter 14 Quenched Hydrogen Exchange NMR of Amyloid Fibrils
  16. Altmetric Badge
    Chapter 15 Studying the Early Stages of Protein Aggregation Using Replica Exchange Molecular Dynamics Simulations
  17. Altmetric Badge
    Chapter 16 Computational Methods for Structural and Functional Studies of Alzheimer's Amyloid Ion Channels.
  18. Altmetric Badge
    Chapter 17 Analyzing Ensembles of Amyloid Proteins Using Bayesian Statistics
  19. Altmetric Badge
    Chapter 18 In Vitro Studies of Membrane Permeability Induced by Amyloidogenic Polypeptides Using Large Unilamellar Vesicles
  20. Altmetric Badge
    Chapter 19 Cell Models to Study Cell-to-Cell Transmission of α-Synuclein.
  21. Altmetric Badge
    Chapter 20 Preparation of Amyloid Fibrils Seeded from Brain and Meninges.
Attention for Chapter 19: Cell Models to Study Cell-to-Cell Transmission of α-Synuclein.
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

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Chapter title
Cell Models to Study Cell-to-Cell Transmission of α-Synuclein.
Chapter number 19
Book title
Protein Amyloid Aggregation
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-2978-8_19
Pubmed ID
Book ISBNs
978-1-4939-2977-1, 978-1-4939-2978-8
Authors

Bae, Eun-Jin, Lee, He-Jin, Lee, Seung-Jae, Eun-Jin Bae, He-Jin Lee, Seung-Jae Lee

Abstract

The cell-to-cell transmission of protein aggregates has been implicated in the progression of pathological phenotypes in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. In recent years, several experimental model systems have been developed to study the mechanisms of cell-to-cell transmission. Herein, we describe cell culture models with which cell-to-cell transmission of α-synuclein can be quantitatively analyzed. The principle underlying these models could be applied to developing model systems for transmission of other protein aggregates, such as tau and TDP-43.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 19%
Student > Bachelor 3 14%
Researcher 3 14%
Student > Doctoral Student 2 10%
Professor > Associate Professor 2 10%
Other 5 24%
Unknown 2 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 33%
Agricultural and Biological Sciences 5 24%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Computer Science 1 5%
Psychology 1 5%
Other 4 19%
Unknown 2 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2015.
All research outputs
#2,943,607
of 22,830,751 outputs
Outputs from Methods in molecular biology
#594
of 13,126 outputs
Outputs of similar age
#52,942
of 393,540 outputs
Outputs of similar age from Methods in molecular biology
#102
of 1,470 outputs
Altmetric has tracked 22,830,751 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,126 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 393,540 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 1,470 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.