Table of Contents

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   Book Overview
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   Chapter 1 Functional Principles Implied in Neurological Symptoms
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   Chapter 2 The Neurobiology of Alzheimer’s Disease
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   Chapter 3 Role of Brain Monoamines and Other Neurotransmitters in Normal and Pathological Aging
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   Chapter 4 Molecular Genetics of Alzheimer’s Disease
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   Chapter 5 Proteins and Proteolysis in the Pathogenesis of Alzheimer’s Disease
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   Chapter 6 Amyloid β Protein Precursors having Proteinase Inhibitor Regions are Highly Expressed in Alzheimer’s Disease Brains
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   Chapter 7 Differential Expression of Three Types of Amyloid Protein Precursor mRNA in Alzheimer’s Disease Brain
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   Chapter 8 Protease Inhibitor and Cholinergic System in Alzheimer’s Disease
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    Chapter 9 Structure and Expression of mRNA for the Mouse Homolog of Alzheimer Amyloid Beta Protein Precursor
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    Chapter 10 Molecular Cloning and Structural Analysis of the Human Amyloid ß Protein Precursor Gene
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    Chapter 11 Protease Nexin 1 Immunoreactivity in Senile Plaques in Alzheimer Disease and Aged Brain
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    Chapter 12 Monoclonal Antibodies Against Senile Plaque Amyloid in Alzheimer’s Disease
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    Chapter 13 Identification of Putative Amyloid A4-Splitting Enzymes with Two Endopeptidases Widely Distributed in Mammalian Cells
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    Chapter 14 Proteolytic Processing of β-Protein Precursor-Related Synthetic Peptides
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    Chapter 15 Degeneration of Neuronal Processes in Rats Induced by the Protease Inhibitor Leupeptin
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    Chapter 16 α 1-Antichymotrypsin Influences the Survival of Neurons
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    Chapter 17 Evidence for a Neuronal Origin of Senile Plaques in Down’s Syndrome Brains
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    Chapter 18 Serum Amyloid P Immunoreactivity in Cortical Tangles, Plaques and Vessels in Alzheimer’s Disease: Implications for Dysfunction of the Blood-Brain Barrier?
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    Chapter 19 Monoamine Oxidase B Activity in Senile Plaque
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    Chapter 20 Light and Electron Microscopic Observations of Diffuse Plaque and Its Related Conditions
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    Chapter 21 β-Amyloid Plaques and Dementia: An Immunohistochemical Study
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    Chapter 22 Diagnosis of Cerebral Amyloid Angiopathy with Cerebral Hemorrhage by Enzyme-Linked Immunosorbent Assay (ELISA) of Cystatin C in Cerebrospinal Fluid
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    Chapter 23 Cystatin C (γ-Trace) and β-Protein Coexist in the Cerebral Amyloid Angiopathy Causing Cerebral Hemorrhage and Consequential Vascular Dementia
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    Chapter 24 The Regulation of Cytoskeletal Elements in Differentiating Human Neuroblastoma and Rat Pheochromocytoma PC-12 Cells
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    Chapter 25 Some Findings on Intermediate Filaments in Alzheimer’s Disease
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    Chapter 26 A Unifying Hypothesis on the Etiology of Alzheimer’s Disease
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    Chapter 27 Abnormal Phospholipid Metabolism in Neurodegenerative Diseases: Elevations in Glycerophosphocholine and Glycerophospho-Ethanolamine Levels in Brain of Alzheimer’s Disease But Not in Down Syndrome Patients
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    Chapter 28 Alterations in Catecholamine and Peptide Neurons in the Locus Coeruleus in Dementias of Alzheimer’s and Parkinson’s Disease
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    Chapter 29 The Role of Neuronal Membranes Deterioration in The Pathogenesis of Alzheimer’s Disease: An Ultrastructural Perspective
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    Chapter 30 Experimental Synaptic Degeneration as a Model for the Pathogenesis of Alzheimer’s Disease: Monoclonal Antibodies and a Protein Kinase Inhibitor Block Synapse Formation and Maintenance Between Cultured CNS Neurons
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    Chapter 31 Pathobiochemical Aspects of Parkinson’s Disease and Dementia of Alzheimer Type
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    Chapter 32 Characterization of Alzheimer Neurofibrillary Tangle (NFT) Epitopes and the Binding Site for the Regulatory Subunit (RII) of cAMP-Dependent Protein Kinase II in Human Microtubule-Associated Protein 2 (MAP-2)
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    Chapter 33 Identification and Characterization of Modified Forms of Tau in Brains with Alzheimer’s Disease
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    Chapter 34 Phosphorylation of Tau Protein with a Novel Tau Protein Kinase Forming Paired Helical Filament Epitopes on Tau
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    Chapter 35 Aberration of Vimentin Array in Fibroblast from Familial Alzheimer’s Disease
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    Chapter 36 Regional Phospholipid Profile of Alzheimer’s Brain
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    Chapter 37 Age-Related Changes in the Rate and Composition of the Slow Axonal Transport
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    Chapter 38 Astroglial Gene Expression in the Hippocampus Following Partial Deafferentation in the Rat and in Alzheimer’s Disease
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    Chapter 39 Blood-Brain Barrier Disturbance in Patients with Alzheimer’s Disease is Related to Vascular Factors
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    Chapter 40 An Early Change of Neurofibrillary Tangle Formation
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    Chapter 41 Monoclonal Antibodies Against Paired Helical Filament in Alzheimer’s Disease and Parkinsonism-Dementia Complex of Guam
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    Chapter 42 Patterns of Vulnerability of Mesostriatal Neurons
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    Chapter 43 Complex I Deficiency in Parkinson’s Disease and MPTP-Induced Experimental Parkinsonism
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    Chapter 44 Biochemical Reactions Leading to Parkinsonian Symptoms Elicited by MPTP
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    Chapter 45 Enzymological Aspects of the Actions of the Parkinsonism-Inducing Neurotoxin MPTP
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    Chapter 46 Biochemical Studies on Predisposition to Parkinson’s Disease
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    Chapter 47 Parkinsoism Produced by an Endogenous Substance, Tetrahydroisoquinoline, in Monkeys and Mice
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    Chapter 48 Tetrahydroisoquinoline Alkaloids in Neurodegenerative Disorders - Influence of Drug Treatment
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    Chapter 49 Chronic L-Dopa Therapy in Parkinson’s Disease: Can It Accelerate Degeneration of Nigrostriatal Dopaminergic Neurons?
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    Chapter 50 Iron-Melanin Interaction in Substantia Nigra as the Neurotoxic Component of Parkinson’s Disease
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    Chapter 51 Dopamine Immunocytochemistry in the Nigrostriatal System of Pre- and Postnatal Mice
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    Chapter 52 The Effects of N-Metyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Administration to Maternal Mice on the Catecholamine System in the Brain of Postnatal Mice
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    Chapter 53 Mitochondrial Abnormalities in the Nigral Neurons of Crab-Eating Monkeys with Experimental Parkinsonism
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    Chapter 54 L-DOPA-Induced Facilitation of Dopamine Release VIA Presynaptic β-Adrenoceptors in Striatal Slices from MPTP-Treated C57BL Mice: Evaluation of the Action of L-DOPA in Animal Model for Parkinsonism
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    Chapter 55 Functional Alterations in Striatal Cholinergic and Striato-Nigral Gaba-Ergic Neurons Following 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Administration
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    Chapter 56 Hemiparkinsonism in Monkeys After Unilateral Striatum Infusion of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)
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    Chapter 57 Cyclosporin a Enhances Neurotoxicity of N-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) in Mice
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    Chapter 58 Effects of Various Drugs on Behavior and Striatal Dopamine Contents in MPTP-Treated Mice Exposed to Stress
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    Chapter 59 Acute Effects of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) on Body Temperature of Various Strains of Mice
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    Chapter 60 Effect of MPP + and TIQ on Cultured Rat Midbrain Dopaminergic Neurons
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    Chapter 61 Assay System for Neurotoxicants Causing Parkinson’s Disease: 1-Methyl-4-Phenylpyridinium Ion (MPP + ) Inhibits Survival of Cultured Neurons from Substantia Nigra of Fetal Monkey( Macaca fascicularis )
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    Chapter 62 The Effect of Tetrahydroisoquinoline on the Mitochondrial Respiration
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    Chapter 63 Detection of Tetrahydroisoquinoline, a Parkinsonism-Related Compound, in Parkinsonian Brains and Foods by Gas Chromatography-Mass Spectrometry
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    Chapter 64 Biosynthesis of N-Methylisoquinolinium Ion, a Potent Inhibitor of Catecholamine Metabolism, from 1,2,3,4-Tetrahydroisoquinoline Through N-Methyl-1,2,3,4-Tetrahydroisoquinoline in Human Brain
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    Chapter 65 Importance of 1-Methyltetrahydroisoquinoline (1MeTIQ) in Parkinson’s Disease
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    Chapter 66 Formation of a Novel and Neurotoxic Tetrahydroisoquinoline Derivative, 1,3-Dimethyltetrahydroisoquinoline (1, 3DiMeTIQ), a Condensation Product of Amphetamines and Acetaldehyde in Vivo
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    Chapter 67 Tryptophan Metabolites in Parkinson’s Brain
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    Chapter 68 A Parallel Relationship between Parkinson’s Disease and an Excess of S-Adenosylmethionine-Dependent Biological Methylation in the Brain
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    Chapter 69 Dopa and Dopamine Cause the Destruction of Cultured Nerve Cells in the Presence of Iron: Possible Mechanism of the Nigral Degeneration in Parkinson’s Disease
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    Chapter 70 Food-Derived Heterocyclic Amines as Potent Inhibitors of Catecholamine Metabolism
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    Chapter 71 Senile Changes in the Human Olfactory Bulbs
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    Chapter 72 Large Neurons in the Neostriatum and Basal Nucleus of Meynert: Simultaneous Decrease in Alzheimer’s Disease
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    Chapter 73 A Comparison of “Pure” Alzheimer’s Disease and Alzheimer’s Disease Plus Vascular Lesions (Mixed Dementia) in the Elderly
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    Chapter 74 Choline Acetyltransferase and Substance P Level in Alzheimer’s Disease and Multi-Infarct Dementia
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    Chapter 75 A Study on Postmortem Changes in Vasopressin mRNA in Rat Brain Using a Non-Isotopic Method
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    Chapter 76 Topographical Distribution, Fine Structure of Component Fibrils, and Immunoreactivity of Neuronal Inclusions in Alzheimer’s, Parkinson’s, and Pick’s Diseases
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    Chapter 77 Neuronal Loss in the Substantia Nigra and Ventral Tegmental Area in Parkinson’s Disease and Alzheimer’s Disease
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    Chapter 78 Characteristics of Reactive Microglia in Alzheimer’s and Parkinson’s Disease Brain Tissue
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    Chapter 79 Alzheimer - Parkinson Disease Spectrum and Diffuse Lewy Body Disease
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    Chapter 80 Acetylcholinesterase Histochemical Changes in the Cerebral Cortex of Alzheimer’s Disease
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    Chapter 81 Basement Membrane Components in Alzheimer’s Disease
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    Chapter 82 Regulation of Cerebral Cortical and Hippocampal Blood Flow by Cholinergic Fibers Originating in the Nucleus Basalis of Meynert and Septal Complex
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    Chapter 83 Immune System Reaction to Model Lesions of Rat Brain
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    Chapter 84 Computer-Aided Quantitative Analysis of the Distribution of Catecholamine-Containing Fibers in the Primate Prefrontal Cortex
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    Chapter 85 Nigrostriatal Loop Disruption in Parkinson’s Disease and Striatonigral Degeneration
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    Chapter 86 Immunocytochemical Studies of Substance P and Met-Enkephalin in the Globus Pallidus of Progressive Supranuclear Palsy
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    Chapter 87 Heterogeneous Distribution of L-DOPA Immunoreactivity in Dopaminergic Neurons of the Rat Midbrain
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    Chapter 88 Cholinergic Systems in Alzheimer’s Disease, Parkinson’s Disease and Progressive Supranuclear Palsy
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    Chapter 89 Neurochemical Aspects of Parkinson’s Disease and the Dementing Brain Disorders: Relation to Brain Ageing
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    Chapter 90 Neuropharmacology and Functional Anatomy of the Basal Ganglia: Experimental Models for Parkinson’s and Alzheimer’s Disease
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    Chapter 91 Neurotransmitter Changes in Alzheimer-Type Dementia and Therapeutic Strategies
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    Chapter 92 In Vitro Experimental Approach for Determination of the Central Cholinergic Neuronal Activity
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    Chapter 93 Pharmacological Profile of Brain Glucose Utilization Obtained by Monitoring of Lactate Release in Vivo under the Free Moving Condition
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    Chapter 94 Behavioral and Neurochemical Evaluation of Stroke-Prone Spontaneously Hypertensive Rats for Vascular Dementia-Animal Model
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    Chapter 95 Acetylcholinesterase of Cerebral Microvessels Changes in Alzheimer’s Disease
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    Chapter 96 Genes of Human Catecholamine-Synthesizing Enzymes
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    Chapter 97 Gene Activity and Neurodegeneration in the Extrapyramidal System: A Progress Report on Molecular and Morphological Correlates
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    Chapter 98 Analysis of Dopamine and Neuropeptides in 6-OHDA-Lesioned Rats
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     Chapter 99 Enhancement of in Vivo Dopamine Release from the Rat Striatum by 6R-L-Erythro-5,6,7,8-Tetrahydrobiopterin as Studied by Brain Dialysis
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     Chapter 100 Preparation of Antigen and Antibody to 3-Methoxy-4-Hydroxyphenyl Glycol(MHPG)
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     Chapter 101 Study of Central Putative Neurotransmitters in Rodent Models of Parkinsonism
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     Chapter 102 Possible Factors Responsible for Adverse Effects of Long-Term L-Dopa Therapy: Simultaneous Determinations of Dopamine Parameters in Rats
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     Chapter 103 Generating and Controlling Multiparameter Data Bases for Biochemical Correlates of Disorders
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     Chapter 104 NEUBA ® : A Multicolumn, Multidetector Liquid Chromatograph with Electrochemical Detection for Use in the Identification and Determination of Neurochemicals and Related Species
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     Chapter 105 Examination of Central Nervous System Effects of Amphetamine Using NEUBA ®
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     Chapter 106 Application of Multi-Dimensional Liquid Chromatography (NEUBA ® ) to the Determination of Neuronal Changes in an Organism
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     Chapter 107 Patterns of Tyrosine and Tryptophan Metabolites in Controls and Various Degenerative Disorders
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     Chapter 108 Dementia in Parkinson’s Disease and Central Cholinergic Function
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     Chapter 109 Subtypes of Nicotinic Receptors in Human Cortex: Selective Changes in Alzheimer Disease
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     Chapter 110 Alterations in Muscarinic Cholinergic Receptors and the Second Messenger System in the Cerebral Cortex in Alzheimer-Type Dementia
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     Chapter 111 Expression of Nicotinic Acetylcholine Receptor mRNA in the Rat Cerebral Cortex after Lesioning of the Nucleus Basalis Magnocellularis
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     Chapter 112 Studies of Central Nervous System Cholinergic Receptors in Alzheimer’s Disease (AD)
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     Chapter 113 Cerebellar Excitatory Amino Acid Binding Sites are Differentially Altered in Alzheimer’s Disease
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     Chapter 114 Pre- and Postsynaptic Cortical Glutamatergic Binding Sites in Alzheimer’s Disease
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     Chapter 115 Reduced N-Methyl-D-Aspartate (NMDA) Receptor-Ion Channel Complex in Alzheimer’s Disease Frontal Cortex
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     Chapter 116 The Influence of Priming on the Behavioral Expression of Dopamine Receptor Supersensitivity in Basal Ganglia
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     Chapter 117 M1 Receptors Stimulate Dopamine Release Via Protein Kinase C in the Striatum of Freely Moving Rat Studied by Brain Dialysis
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     Chapter 118 Effect of MPTP on Dopamine D 2 Receptors in the Aging Mouse Striatum
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     Chapter 119 Age-Dependent Effects of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) in the Rat
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     Chapter 120 More Rapid Development of Supersensitivity of D-2 Receptors than D-1 Receptors as Examined by Rotational Behavior
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     Chapter 121 Features of the Dopaminergic Neurotoxicity of Methamphetamine: A Comparison with MPTP
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     Chapter 122 Alteration of [ 3 H] Ins (1,4,5) P 3 and [ 3 H] PDBu Binding Sites in Brains of Patients with Parkinson’s Disease and Multiple System Atrophy
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     Chapter 123 The Mechanism of Action of Nerve Growth Factor
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     Chapter 124 Nerve Growth Factor Promotes Survival of Cultured Cholinergic Neurons from Nucleus Basalis of Meynert of 2-Week-Old Rats
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     Chapter 125 Alterations in Nerve Growth Factor Receptor Containing Neurons in Parkinson’s Disease
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     Chapter 126 A Striatal-Derived DA Neuron Growth Factor: Implication in Parkinson’s Disease
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     Chapter 127 Co-Localization of Cholinergic and GABAergic Traits in in Vitro Septohippocampal Neurons from Developing Rats
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     Chapter 128 A Hippocampal Cell Line Expresses a Membrane-Associated Cholinergic Trophic Activity Not Attributable to Nerve Growth Factor
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     Chapter 129 Interleukin-6 as a Neurotrophic Factor for Promoting Survival of Septal Cholinergic Neurons and Mesencephalic Catecholaminergic Neurons from Postnatal Rats
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     Chapter 130 Distribution of NGF Receptors in Control and Alzheimer’s Disease Basal Forebrain
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     Chapter 131 Trophic Effects of Hippocampus Cell Membrane Fragments on Cultured Medial Septal Cholinergic Neurons
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     Chapter 132 Changes in Basal Forebrain Cholinergic Systems Following Excitotoxic Cell Death in the Hippocampus and Cerebral Neocortex
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     Chapter 133 Interleukin-3 Promotes Neurite Outgrowth and Elevates Choline Acetyltransferase Activity
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     Chapter 134 Memory Impairment in Rats Induced by an Active Fragment of Nerve Growth Factor Antibody
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     Chapter 135 Brain’s Calculating Principle
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     Chapter 136 Screening for Psychotherapeutic Chemicals by Analysis of Conscious Activity in the Mouse
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     Chapter 137 Regulation of Neocortical Electrical Activity by Cholinergic and Noradrenergic Systems
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     Chapter 138 Ascending Cholinergic and Monoaminergic Systems in the Brainstem: Do they Constitute a Reticular Activating System?
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     Chapter 139 Role of the Medial Limbic System in the Memory Process: A Hypothesis Based on a Radioactive 2-Deoxyglucose Study
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     Chapter 140 Effect of Magnetism on Learning Function
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     Chapter 141 Morphological Changes of the Brain in Senescence Accelerated Mouse (SAM)-P/8, a Newly Developed Memory-Deficient Strain
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     Chapter 142 Age-Related Changes in Blood-Brain Barrier ( BBB )
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     Chapter 143 Effect of Aging on NADPH-Diaphorase Neurons in Laterodorsal Tegmental Nucleus and Striatum of Senescence Accelerated Mouse (SAM)
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     Chapter 144 Senescence-Accelerated Mouse SAM-P/8 Shows Spontaneous Age-Related Impairment of Ability of Acquisition of Learning and Memory: An Animal Model of Disturbances in Recent Memory with Aging
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     Chapter 145 An Experimental Animal Model for the Study of Cholinergic and Serotonergic Neuronal Activity in Aging Brain
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     Chapter 146 Aging Effects on Schedule-Control Discrimination Learning Test in Aged Rats as a Model of Alzheimer’s Disease
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     Chapter 147 Effect of the Basal Forebrain Lesions on Memory and Learning Performance in Mice
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     Chapter 148 Effects of Destruction of Nucleus Basalis Meynert on Operant Study and Neurotransmitters in Rats
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     Chapter 149 Characteristic of Learning Deficit Induced by Ibotenic Acid Lesion of the Frontal Cortex Related with the Nucleus Basalis of Meynert in Rats
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     Chapter 150 A New Animal Model of Alzheimer’s Disease by Selective Destruction of the Cholinergic Neurons in the Basal Forebrain
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     Chapter 151 Impairment of Avoidance Behavior Produced by Destruction of the Cholinergic Projection from the Pedunculopontine Nucleus to the Medial Thalamus
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     Chapter 152 Impaired Spatial Learning in Rats with a Trimethyltin-Induced Hippocampal Lesion and the Effect of Fetal Septal Grafting on the Impairment
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     Chapter 153 Some Effects of CNS Cholinergic Neurons on Memory and ACh Release
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     Chapter 154 Carbon Monoxide (CO)-Induced Delayed Amnesia and Delayed Neuronal Death
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     Chapter 155 Modifications in the Levels of Antibodies in the CSF of Parkinson’s Disease Patients Following Adrenal-to-Brain Transplantation
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     Chapter 156 Autotransplantation of Parasympathetic Cholinergic Neurons into Alzheimer Model Rat Brain
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     Chapter 157 Use of MPTP-Hemiparkinsonian (HP) Monkeys to Evaluate Efficacy of Tissue Implants as a Treatment for Parkinson’s Disease
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     Chapter 158 Autotransplantation of Sympathetic Ganglion into the Brain of Parkinsonian Monkey
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     Chapter 159 Long-Term Survival of Grafted Cells, Dopamine Synthesis/Release, Receptor Activity, and Functional Recovery after Grafting of Fetal Nigral Cells in Model Animals of Hemi-Parkinson’s Disease
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     Chapter 160 Intra-Accumbens Dopaminergic Grafts Restore Methamphetamine-Induced Locomotor Hyperactivity Response and the Release and Metabolism of Dopamine in Rats Having 6-OHDA Lesions in the Ventral Tegmental Area
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     Chapter 161 Investigation of MHC Antigens on Neural Graft in Mouse Parkinson’s Models