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Gene Therapy of Solid Cancers

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Cover of 'Gene Therapy of Solid Cancers'

Table of Contents

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    Book Overview
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    Chapter 1 Aptamer Targeting the ERBB2 Receptor Tyrosine Kinase for Applications in Tumor Therapy
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    Chapter 2 Gene Gun Her2/neu DNA Vaccination: Evaluation of Vaccine Efficacy in a Syngeneic Her2/neu Mouse Tumor Model.
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    Chapter 3 MIDGE Technology for the Production of a Fourfold Gene-Modified, Allogenic Cell-Based Vaccine for Cancer Therapy.
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    Chapter 4 Evaluation of Bystander Cell Killing Effects in Suicide Gene Therapy of Cancer: Engineered Thymidylate Kinase (TMPK)/AZT Enzyme-Prodrug Axis
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    Chapter 5 Oncoleaking: Use of the Pore-Forming Clostridium perfringens Enterotoxin (CPE) for Suicide Gene Therapy
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    Chapter 6 iCaspase 9 Suicide Gene System.
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    Chapter 7 p53-Encoding pDNA Purification by Affinity Chromatography for Cancer Therapy
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    Chapter 8 A qRT-PCR Method for Determining the Biodistribution Profile of a miR-34a Mimic.
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    Chapter 9 Design and Selection of Antisense Oligonucleotides Targeting Transforming Growth Factor Beta (TGF-β) Isoform mRNAs for the Treatment of Solid Tumors.
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    Chapter 10 RNA Interference for Antimetastatic Therapy
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    Chapter 11 STAT3 Decoy ODN Therapy for Cancer.
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    Chapter 12 Oncolytic Viral Therapy Using Reovirus
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    Chapter 13 Use of GLV-1h68 for Vaccinia Virotherapy and Monitoring
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    Chapter 14 Back to the Future: Are Tumor-Targeting Bacteria the Next-Generation Cancer Therapy? - PubMed - NCBI
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    Chapter 15 Ethics of Cancer Gene Transfer Clinical Research
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    Chapter 16 Planning an Academic Clinical Trial
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    Chapter 17 Production of Plasmid DNA as Pharmaceutical
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    Chapter 18 Minicircle: Next Generation DNA Vectors for Vaccination.
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    Chapter 19 A Phase 2, Open-Label, Randomized Study of Pexa-Vec (JX-594) Administered by Intratumoral Injection in Patients with Unresectable Primary Hepatocellular Carcinoma.
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    Chapter 20 Antiangiogenic Metargidin Peptide (AMEP) Gene Therapy in Disseminated Melanoma.
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    Chapter 21 Clinical Evaluation of ErbB-Targeted CAR T-Cells, Following Intracavity Delivery in Patients with ErbB-Expressing Solid Tumors.
Attention for Chapter 15: Ethics of Cancer Gene Transfer Clinical Research
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Chapter title
Ethics of Cancer Gene Transfer Clinical Research
Chapter number 15
Book title
Gene Therapy of Solid Cancers
Published in
Methods in molecular biology, January 2015
DOI 10.1007/978-1-4939-2727-2_15
Pubmed ID
Book ISBNs
978-1-4939-2726-5, 978-1-4939-2727-2
Authors

Jonathan Kimmelman, Kimmelman, Jonathan

Abstract

Translation of cancer gene transfer confronts many familiar-and some distinctive-ethical challenges. In what follows, I survey three major ethical dimensions of cancer gene transfer development. Subheading 1 centers on the ethics of planning, designing, and reporting animal studies. Subheading 2 describes basic elements of human subjects protection as pertaining to cancer gene transfer. In Subheading 3, I describe how cancer gene transfer researchers have obligations to downstream consumers of the evidence they produce.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
Colombia 1 3%
Australia 1 3%
Unknown 35 92%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 24%
Student > Master 5 13%
Researcher 5 13%
Student > Ph. D. Student 4 11%
Student > Doctoral Student 2 5%
Other 4 11%
Unknown 9 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 29%
Biochemistry, Genetics and Molecular Biology 9 24%
Nursing and Health Professions 3 8%
Medicine and Dentistry 2 5%
Engineering 2 5%
Other 2 5%
Unknown 9 24%