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Chapter title |
Use of GLV-1h68 for Vaccinia Virotherapy and Monitoring
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Chapter number | 13 |
Book title |
Gene Therapy of Solid Cancers
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Published in |
Methods in molecular biology, January 2015
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DOI | 10.1007/978-1-4939-2727-2_13 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2726-5, 978-1-4939-2727-2
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Authors |
Alexa Frentzen, Ulrike Geissinger, Desislava Tsoneva, Jochen Stritzker, Frentzen, Alexa, Geissinger, Ulrike, Tsoneva, Desislava, Stritzker, Jochen |
Abstract |
Herein we describe the use of the vaccinia virus strain GLV-1h68 as a theragnostic agent in cancer models. To date, GLV-1h68 has been used successfully in more than 50 xenograft tumor models. The recombinant vaccinia virus strain has been equipped with heterologous expression cassettes for a luciferase-fluorescent protein fusion gene, bacterial beta-galactosidase, as well as a bacterial glucuronidase.The methods to investigate and monitor GLV-1h68 mediated virotherapy, including optical imaging and biomarker analysis, will be presented in detail. |
Mendeley readers
The data shown below were compiled from readership statistics for 1 Mendeley reader of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 1 | 100% |
Readers by discipline | Count | As % |
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Unknown | 1 | 100% |