| Chapter title |
Controlling Autolysis During Flagella Insertion in Gram-Negative Bacteria
|
|---|---|
| Chapter number | 52 |
| Book title |
Protein Reviews
|
| Published in |
Advances in experimental medicine and biology, January 2016
|
| DOI | 10.1007/5584_2016_52 |
| Pubmed ID | |
| Book ISBNs |
978-9-81-103709-2, 978-9-81-103710-8
|
| Authors |
Francesca A. Herlihey, Anthony J. Clarke |
| Abstract |
The flagellum is an important macromolecular machine for many pathogenic bacteria. It is a hetero-oligomeric structure comprised of three major sub-structures: basal body, hook and thin helical filament. An important step during flagellum assembly is the localized and controlled degradation of the peptidoglycan sacculus to allow for the insertion of the rod as well as to facilitate anchoring for proper motor function. The peptidoglycan lysis events require specialized lytic enzymes, β-N-acetylglucosaminidases and lytic transglycosylases, which differ in flagellated proteobacteria. Due to their autolytic activity, these enzymes need to be controlled in order to prevent cellular lysis. This review summarizes are current understanding of the peptidoglycan lysis events required for flagellum assembly and motility with a main focus on Gram-negative bacteria. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 17% |
| Researcher | 5 | 17% |
| Student > Bachelor | 4 | 13% |
| Student > Master | 2 | 7% |
| Student > Doctoral Student | 1 | 3% |
| Other | 3 | 10% |
| Unknown | 10 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 40% |
| Agricultural and Biological Sciences | 4 | 13% |
| Immunology and Microbiology | 2 | 7% |
| Chemistry | 1 | 3% |
| Unknown | 11 | 37% |