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Pulmonary Dysfunction and Disease

Overview of attention for book
Attention for Chapter 16: Effect of Simulated Microgravity and Lunar Gravity on Human Inspiratory Muscle Function: ‘Selena-T’ 2015 Study
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Chapter title
Effect of Simulated Microgravity and Lunar Gravity on Human Inspiratory Muscle Function: ‘Selena-T’ 2015 Study
Chapter number 16
Book title
Pulmonary Dysfunction and Disease
Published in
Advances in experimental medicine and biology, January 2016
DOI 10.1007/5584_2016_16
Pubmed ID
Book ISBNs
978-3-31-942009-7, 978-3-31-942010-3

M. O. Segizbaeva, N. P. Aleksandrova, Z. A. Donina, E. V. Baranova, V. P. Katuntsev, G. G. Tarasenkov, V. M. Baranov


As a part of the multi-disciplinary "SELENA-T"-2015 Bed Rest Study, we investigated the pattern of inspiratory muscles fatigue in 22 healthy male subjects during incremental exercise test to exhaustion before and after 21 days of hypokinesia evoked by bed rest. Hypokinesia consisted of head-down bed rest (HDBR) at a minus 6° angle, simulating microgravity present on orbiting spacecraft, in 10 subjects. The remaining 12 subjects spent the first 5 days of hypokinesia in HDBR position and the subsequent 16 days in head-up bed rest (HUBR) at a plus 9.6° angle, as a presumed analog of lunar gravity that is six times less than Earth's gravity. Maximal inspiratory pressure (MIP) and electromyograms (EMG) of the diaphragm (D), parasternal (PS), sternocleidomastoid (SCM), and scalene (S) muscles served as indices of inspiratory muscle function. Before both HDBR and HUBR, exercise decreased MIP and centroid frequency (fc) of EMG (D, PS, SCM, and S) power spectrum (p < 0.05). After 3 weeks of HDBR, but not HUBR, inspiratory muscles fatigue was more expressed compared with control (p < 0.05). We conclude that HDBR lowers inspiratory muscles resistance to fatigue during high-intensity exercise while HUBR has no such effect. These changes may limit maximal ventilation and may contribute to exercise intolerance observed after prolonged simulated microgravity. The physiological mechanisms of respiratory muscle dysfunction after HDBR consist primarily of postural effects, and are not due only to hypokinesia.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 25%
Student > Doctoral Student 3 25%
Professor 1 8%
Librarian 1 8%
Researcher 1 8%
Other 0 0%
Unknown 3 25%
Readers by discipline Count As %
Sports and Recreations 2 17%
Physics and Astronomy 1 8%
Earth and Planetary Sciences 1 8%
Medicine and Dentistry 1 8%
Neuroscience 1 8%
Other 0 0%
Unknown 6 50%