Chapter title |
Calibration-Quality Cancer Nanotherapeutics
|
---|---|
Chapter number | 12 |
Book title |
Nanotechnology-Based Precision Tools for the Detection and Treatment of Cancer
|
Published in |
Cancer treatment and research, January 2015
|
DOI | 10.1007/978-3-319-16555-4_12 |
Pubmed ID | |
Book ISBNs |
978-3-31-916554-7, 978-3-31-916555-4
|
Authors |
Jillian L. Perry, Marc P. Kai, Kevin G. Reuter, Charles Bowerman, J. Christopher Luft, Joseph M. DeSimone, Perry, Jillian L., Kai, Marc P., Reuter, Kevin G., Bowerman, Charles, Christopher Luft, J., DeSimone, Joseph M. |
Abstract |
Nanoparticle properties such as size, shape, deformability, and surface chemistry all play a role in nanomedicine drug delivery in cancer. While many studies address the behavior of particle systems in a biological setting, revealing how these properties work together presents unique challenges on the nanoscale. "Calibration-quality" control over such properties is needed to draw adequate conclusions that are independent of parameter variability. Furthermore, active targeting and drug loading strategies introduce even greater complexities via their potential to alter particle pharmacokinetics. Ultimately, the investigation and optimization of particle properties should be carried out in the appropriate preclinical tumor model. In doing so, translational efficacy improves as clinical tumor properties increase. Looking forward, the field of nanomedicine will continue to have significant clinical impacts as the capabilities of nanoparticulate drug delivery are further enhanced. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 13% |
Unknown | 7 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 3 | 38% |
Lecturer > Senior Lecturer | 2 | 25% |
Student > Ph. D. Student | 1 | 13% |
Unknown | 2 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Materials Science | 2 | 25% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 13% |
Agricultural and Biological Sciences | 1 | 13% |
Medicine and Dentistry | 1 | 13% |
Unknown | 3 | 38% |