Chapter title |
Synthetic High-Density Lipoprotein-Like Nanoparticles as Cancer Therapy
|
---|---|
Chapter number | 6 |
Book title |
Nanotechnology-Based Precision Tools for the Detection and Treatment of Cancer
|
Published in |
Cancer treatment and research, January 2015
|
DOI | 10.1007/978-3-319-16555-4_6 |
Pubmed ID | |
Book ISBNs |
978-3-31-916554-7, 978-3-31-916555-4
|
Authors |
Kaylin M. McMahon, Linda Foit, Nicholas L. Angeloni, Francis J. Giles, Leo I. Gordon, C. Shad Thaxton, McMahon, Kaylin M, Foit, Linda, Angeloni, Nicholas L, Giles, Francis J, Gordon, Leo I, Thaxton, C Shad, McMahon, Kaylin M., Angeloni, Nicholas L., Giles, Francis J., Gordon, Leo I., Thaxton, C. Shad |
Abstract |
High-density lipoproteins (HDL) are diverse natural nanoparticles that carry cholesterol and are best known for the role that they play in cardiovascular disease. However, due to their unique targeting capabilities, diverse molecular cargo, and natural functions beyond cholesterol transport, it is becoming increasingly appreciated that HDLs are critical to cancer development and progression. Accordingly, this chapter highlights ongoing research focused on the connections between HDL and cancer in order to design new drugs and targeted drug delivery vehicles. Research is focused on synthesizing biomimetic HDL-like nanoparticles (NP) that can be loaded with diverse therapeutic cargo (e.g., chemotherapies, nucleic acids, proteins) and specifically targeted to cancer cells. Beyond drug delivery, new data is emerging that HDL-like NPs may be therapeutically active in certain tumor types, for example, B cell lymphoma. Overall, HDL-like NPs are becoming increasingly appreciated as targeted, biocompatible, and efficient therapies for cancer, and may soon become indispensable agents in the cancer therapeutic armamentarium. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 33% |
Malaysia | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
Germany | 1 | 2% |
France | 1 | 2% |
Unknown | 56 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 17% |
Researcher | 10 | 17% |
Student > Bachelor | 6 | 10% |
Student > Master | 5 | 8% |
Student > Doctoral Student | 4 | 7% |
Other | 7 | 12% |
Unknown | 17 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 10% |
Engineering | 6 | 10% |
Agricultural and Biological Sciences | 6 | 10% |
Medicine and Dentistry | 5 | 8% |
Other | 9 | 15% |
Unknown | 20 | 34% |