| Chapter title |
Therapeutic applications of spherical nucleic acids.
|
|---|---|
| Chapter number | 2 |
| Book title |
Nanotechnology-Based Precision Tools for the Detection and Treatment of Cancer
|
| Published in |
Cancer treatment and research, January 2015
|
| DOI | 10.1007/978-3-319-16555-4_2 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-916554-7, 978-3-31-916555-4
|
| Authors |
Barnaby, Stacey N, Sita, Timothy L, Petrosko, Sarah Hurst, Stegh, Alexander H, Mirkin, Chad A, Stacey N. Barnaby, Timothy L. Sita, Sarah Hurst Petrosko, Alexander H. Stegh, Chad A. Mirkin, Barnaby, Stacey N., Sita, Timothy L., Stegh, Alexander H., Mirkin, Chad A. |
| Abstract |
Spherical nucleic acids (SNAs) represent an emerging class of nanoparticle-based therapeutics. SNAs consist of densely functionalized and highly oriented oligonucleotides on the surface of a nanoparticle which can either be inorganic (such as gold or platinum) or hollow (such as liposomal or silica-based). The spherical architecture of the oligonucleotide shell confers unique advantages over traditional nucleic acid delivery methods, including entry into nearly all cells independent of transfection agents and resistance to nuclease degradation. Furthermore, SNAs can penetrate biological barriers, including the blood-brain and blood-tumor barriers as well as the epidermis, and have demonstrated efficacy in several murine disease models in the absence of significant adverse side effects. In this chapter, we will focus on the applications of SNAs in cancer therapy as well as discuss multimodal SNAs for drug delivery and imaging. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 5% |
| France | 1 | 3% |
| Canada | 1 | 3% |
| Unknown | 36 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 28% |
| Researcher | 6 | 15% |
| Student > Master | 5 | 13% |
| Student > Bachelor | 5 | 13% |
| Student > Doctoral Student | 2 | 5% |
| Other | 4 | 10% |
| Unknown | 7 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 20% |
| Chemistry | 7 | 18% |
| Biochemistry, Genetics and Molecular Biology | 6 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 8% |
| Medicine and Dentistry | 3 | 8% |
| Other | 6 | 15% |
| Unknown | 7 | 18% |