CRISPR/RNA-guided nuclease systems and methods Grant US-11963982-B2 United States of America 23 Apr 2024
High efficiency base editors comprising Gam Grant US-11932884-B2 United States of America 19 Mar 2024
Preparation of libraries of protein variants expressed in eukaryotic cells and use for… Grant US-11926818-B2 United States of America 12 Mar 2024
BASE EDITING APPROACHES FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS Application WO-2024047247-A1 World Intellectual Property Organisation (WIPO) 07 Mar 2024
A MULTIPLEXED RNA REGULATION PLATFORM FOR PRIMARY IMMUNE CELL ENGINEERING Application WO-2024044672-A2 World Intellectual Property Organisation (WIPO) 29 Feb 2024
Preparation of libraries of protein variants expressed in eukaryotic cells and use for… Grant US-11912984-B2 United States of America 27 Feb 2024
Methods and compositions for simultaneous editing of both strands of a target double-strand… Grant US-11912985-B2 United States of America 27 Feb 2024
EVOLVED CYTOSINE DEAMINASES AND METHODS OF EDITING DNA USING SAME Application WO-2024040083-A1 World Intellectual Property Organisation (WIPO) 22 Feb 2024
Methods and compositions for the treatment of lysosomal storage diseases Grant US-11898158-B2 United States of America 13 Feb 2024
Synthetic immunomodulation with a CRISPR super-repressor in vivo Grant US-11884925-B2 United States of America 30 Jan 2024
BASE EDITING APPROACHES FOR CORRECTING THE IVS2-1 (G>A) MUTATION IN PATIENTS SUFFERING… Application WO-2024018056-A1 World Intellectual Property Organisation (WIPO) 25 Jan 2024
Cas-ready mouse embryonic stem cells and mice and uses thereof Grant US-11866794-B2 United States of America 09 Jan 2024
Systems and methods for the treatment of hemoglobinopathies Grant US-11851690-B2 United States of America 26 Dec 2023
Methods and means for genetic alteration of genomes utilizing designer DNA recombining… Grant US-11845954-B2 United States of America 19 Dec 2023
METHODS FOR DETECTING GENOMIC ABNORMALITIES IN CELLS Application WO-2023240218-A1 World Intellectual Property Organisation (WIPO) 14 Dec 2023
Editing of CCR2 receptor gene to protect against HIV infection Grant US-11820969-B2 United States of America 21 Nov 2023
Methods and compositions for the targeted modification of a genome Grant US-11820997-B2 United States of America 21 Nov 2023
BASE EDITING APPROACHES FOR CORRECTING THE CD39 (CAG>TAG) MUTATION IN PATIENTS SUFFERING… Application WO-2023217888-A1 World Intellectual Property Organisation (WIPO) 16 Nov 2023
AAV VECTORS ENCODING BASE EDITORS AND USES THEREOF Application WO-2023212715-A1 World Intellectual Property Organisation (WIPO) 02 Nov 2023
IMPROVED PRIME EDITING METHODS AND COMPOSITIONS Application WO-2023205687-A1 World Intellectual Property Organisation (WIPO) 26 Oct 2023
Methods and compositions for prime editing nucleotide sequences Grant US-11795452-B2 United States of America 24 Oct 2023
Methods and compositions for evolving base editors using phage-assisted continuous… Grant US-11732274-B2 United States of America 22 Aug 2023
BASE EDITING APPROACHES FOR THE TREATMENT OF ΒETA-THALASSEMIA Application WO-2023144104-A1 World Intellectual Property Organisation (WIPO) 03 Aug 2023
Adenosine nucleobase editors and uses thereof Grant US-11702651-B2 United States of America 18 Jul 2023
Inhibition of HSD17B13 in the treatment of liver disease in patients expressing the… Grant US-11702700-B2 United States of America 18 Jul 2023
Methods and compositions for targeted genetic modification using paired guide RNAs Grant US-11697828-B2 United States of America 11 Jul 2023
SELF-ASSEMBLING VIRUS-LIKE PARTICLES FOR DELIVERY OF NUCLEIC ACID PROGRAMMABLE FUSION… Application WO-2023102537-A2 World Intellectual Property Organisation (WIPO) 08 Jun 2023
COMPOSITIONS AND METHODS FOR EFFICIENT IN VIVO DELIVERY Application WO-2023102550-A2 World Intellectual Property Organisation (WIPO) 08 Jun 2023
METHODS FOR INCREASING FETAL HEMOGLOBIN CONTENT BY EDITING THE +55-KB REGION OF THE… Application WO-2023099591-A1 World Intellectual Property Organisation (WIPO) 08 Jun 2023
Programmable CAS9-recombinase fusion proteins and uses thereof Grant US-11661590-B2 United States of America 30 May 2023
SITE-SPECIFIC RECOMBINASES FOR EFFICIENT AND SPECIFIC GENOME EDITING Application WO-2023084099-A1 World Intellectual Property Organisation (WIPO) 19 May 2023
Methods of enhancing chromosomal homologous recombination Grant US-11643670-B2 United States of America 09 May 2023
Methods and compositions for prime editing nucleotide sequences Grant US-11643652-B2 United States of America 09 May 2023
BASE EDITING APPROACHES FOR THE TREATMENT OF BETA-HEMOGLOBINOPATHIES Application WO-2023052366-A1 World Intellectual Property Organisation (WIPO) 06 Apr 2023
Compositions and methods for treating CEP290 associated disease Grant US-11566263-B2 United States of America 31 Jan 2023
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and… Grant US-11560566-B2 United States of America 24 Jan 2023
Incorporation of unnatural amino acids into proteins using base editing Grant US-11542509-B2 United States of America 03 Jan 2023
Transcription modulation in animals using CRISPR/Cas systems Grant US-11519004-B2 United States of America 06 Dec 2022
Systems and methods for treating alpha 1-antitrypsin (A1AT) deficiency Grant US-11512311-B2 United States of America 29 Nov 2022
Assays for screening activity of modulators of members of the hydroxy steroid (17-beta… Grant US-11479802-B2 United States of America 25 Oct 2022
Methods and compositions for prime editing nucleotide sequences Grant US-11447770-B1 United States of America 20 Sep 2022
Compositions and methods for treating CEP290-associated disease Grant US-11339437-B2 United States of America 24 May 2022
Methods and compositions for targeted genetic modification through single-step multiple… Grant US-11326184-B2 United States of America 10 May 2022
High efficiency base editors comprising Gam Grant US-11319532-B2 United States of America 03 May 2022
Preparation of libraries of protein variants expressed in eukaryotic cells and use for… Grant US-11286477-B2 United States of America 29 Mar 2022
CRISPR/CAS-related methods and compositions for treating Leber's Congenital Amaurosis 10 (L… Grant US-11268086-B2 United States of America 08 Mar 2022
Nucleobase editors comprising nucleic acid programmable DNA binding proteins Grant US-11268082-B2 United States of America 08 Mar 2022
CRISPR/CAS-related methods and compositions for treating sickle cell disease Grant US-11242525-B2 United States of America 08 Feb 2022
SYNTHETIC IMMUNOMODULATION WITH A CRISPR SUPER-REPRESSOR IN VIVO Application US-20210380990-A1 United States of America 09 Dec 2021
Evaluation of Cas9 molecule/guide RNA molecule complexes Grant US-11180793-B2 United States of America 23 Nov 2021
Compositions and methods for treating CEP290-associated disease Grant US-11141493-B2 United States of America 12 Oct 2021
Cas-ready mouse embryonic stem cells and mice and uses thereof Grant US-11130999-B2 United States of America 28 Sep 2021
FUSION OF SITE-SPECIFIC RECOMBINASES FOR EFFICIENT AND SPECIFIC GENOME EDITING Application WO-2021110846-A1 World Intellectual Property Organisation (WIPO) 10 Jun 2021
FUSION OF SITE-SPECIFIC RECOMBINASES FOR EFFICIENT AND SPECIFIC GENOME EDITING Application EP-3831939-A1 European Patent Office 09 Jun 2021
Methods and compositions for assessing CRISPER/Cas-mediated disruption or excision and… Grant US-11021719-B2 United States of America 01 Jun 2021
Inhibition of HSD17B13 in the treatment of liver disease in patients expressing the… Grant US-10961583-B2 United States of America 30 Mar 2021
RNA-guided DNA integration using Tn7-like transposons Grant US-10947534-B2 United States of America 16 Mar 2021
BASE EDITORS WITH DIVERSIFIED TARGETING SCOPE Application WO-2021025750-A1 World Intellectual Property Organisation (WIPO) 11 Feb 2021
ANTAGONISTS ANTI-CD7 ANTIBODIES Application WO-2020212710-A1 World Intellectual Property Organisation (WIPO) 22 Oct 2020
SYSTEM FOR GENOME EDITING Application WO-2020210751-A1 World Intellectual Property Organisation (WIPO) 15 Oct 2020
METHODS AND COMPOSITIONS FOR CELL THERAPY Application WO-2020206046-A1 World Intellectual Property Organisation (WIPO) 08 Oct 2020
Methods and compositions for targeted genetic modifications and methods of use Grant US-10793874-B2 United States of America 06 Oct 2020
Methods and compositions for the targeted modification of a mouse ES cell genome Grant US-10711280-B2 United States of America 14 Jul 2020
Methods and compositions for targeted genetic modification using paired guide RNAs Grant US-10457960-B2 United States of America 29 Oct 2019
Methods and compositions for generating or maintaining pluripotent cells Application US-10428310-B2 United States of America 01 Oct 2019
Methods and compositions for modifying a targeted locus Grant US-10294494-B2 United States of America 21 May 2019
Methods and compositions for the targeted modification of a mouse embryonic stem cell… Grant US-10208317-B2 United States of America 19 Feb 2019