RT @NovaMarkButler: Not accurate @mclaudebibeau Gene editing using #CRISPR is not just selective breeding sped up. This is an biotech i…
RT @fgidf98fj9jh0h: #CRISPRを使用した遺伝子編集は、単に品種改良をスピードアップするだけではありません。 これはバイオテクノロジー業界の話題ですが、科学的に正確ではありません。 CRISPR により予期しない削除が発生します。
RT @NovaMarkButler: Not accurate @mclaudebibeau Gene editing using #CRISPR is not just selective breeding sped up. This is an biotech i…
RT @NovaMarkButler: Not accurate @mclaudebibeau Gene editing using #CRISPR is not just selective breeding sped up. This is an biotech i…
#CRISPRを使用した遺伝子編集は、単に品種改良をスピードアップするだけではありません。 これはバイオテクノロジー業界の話題ですが、科学的に正確ではありません。 CRISPR により予期しない削除が発生します。
RT @NovaMarkButler: Not accurate @mclaudebibeau Gene editing using #CRISPR is not just selective breeding sped up. This is an biotech i…
RT @NovaMarkButler: Not accurate @mclaudebibeau Gene editing using #CRISPR is not just selective breeding sped up. This is an biotech i…
This is like five-year-olds playing with hand guns.
RT @NovaMarkButler: Not accurate @mclaudebibeau Gene editing using #CRISPR is not just selective breeding sped up. This is an biotech i…
RT @NovaMarkButler: Not accurate @mclaudebibeau Gene editing using #CRISPR is not just selective breeding sped up. This is an biotech i…
RT @NovaMarkButler: Not accurate @mclaudebibeau Gene editing using #CRISPR is not just selective breeding sped up. This is an biotech i…
RT @NovaMarkButler: Not accurate @mclaudebibeau Gene editing using #CRISPR is not just selective breeding sped up. This is an biotech i…
RT @NovaMarkButler: Not accurate @mclaudebibeau Gene editing using #CRISPR is not just selective breeding sped up. This is an biotech i…
RT @NovaMarkButler: Not accurate @mclaudebibeau Gene editing using #CRISPR is not just selective breeding sped up. This is an biotech i…
Not accurate @mclaudebibeau Gene editing using #CRISPR is not just selective breeding sped up. This is an biotech industry talking point but it's not scientifically accurate. CRISPR causes unexpected deletions: https://t.co/3N6Y345s5W
Repair of double-strand breaks induced by CRISPR-Cas9 leads to large deletions and complex rearrangements https://t.co/zagOaSWYKz
RT @mlperk1: Quality Control and Quality Assurance-big topic... https://t.co/uXkp5YG5b1
Quality Control and Quality Assurance-big topic... https://t.co/uXkp5YG5b1
@stuartsmyth66 This research shows that CRISPR/Cas9 gene editing can cause greater genetic damage than was previously thought, arising from the cell’s innate repair machinery that goes into action after the initial targeted https://t.co/DbZM2ylXra
@BiochemistTomas @Kaptkanga1 @MartinReich5 Tomas, please share your thoughts about this: https://t.co/RJL4l2qOPJ
@Michael20258328 @john_evans3 @gciaramella1 @NicoleGaudelli @zhangf @JKeithJoung Do you mean why do nucleases cause translocations but not base editors? Because nucleases make double-stranded DNA breaks but base editors do not. That’s the point of base edi
@Bobby_Corwin tbch the only reason I'm not holding out for CRISPR is because I have recently started working with CRISPR and have come to the conclusion that i just plain cannot trust it to make accurate global edits to my adult human multicellular genome
@Lykos_Phi @kindofmagic4u @thinks_about_it @janusPrime @HalleVerkehrt Vgl. Primärquelle des Artikels: https://t.co/XEuEtvaX6T References 2-12
RT @AfrahBawazeer: في دراسةمثيرة البحث فيNature Biotechnology https://t.co/f0WRSPPs9z تم الكشف عن“انماط أخرى”من أنظمة CRISPR التي لاتتطلب ق…
RT @AfrahBawazeer: في دراسةمثيرة البحث فيNature Biotechnology https://t.co/f0WRSPPs9z تم الكشف عن“انماط أخرى”من أنظمة CRISPR التي لاتتطلب ق…
RT @AfrahBawazeer: في دراسةمثيرة البحث فيNature Biotechnology https://t.co/f0WRSPPs9z تم الكشف عن“انماط أخرى”من أنظمة CRISPR التي لاتتطلب ق…
RT @AfrahBawazeer: في دراسةمثيرة البحث فيNature Biotechnology https://t.co/f0WRSPPs9z تم الكشف عن“انماط أخرى”من أنظمة CRISPR التي لاتتطلب ق…
@AndreyMalinin @RamonAstudill12 This is exactly what appears to have happened with CRISPR-cas9 https://t.co/HlWqOT0XeV
Jonas dives into a few new methods to comprehensively interrogate the entire genome & determine the true outcomes of #geneeditng experiments. #LRcrispr The papers he references: https://t.co/Sjdats2gCW https://t.co/WWC5VZFVTG https://t.co/amT6D9LmF8 h
"Here we report significant on-target mutagenesis, such as large deletions & more complex genomic rearrangements at the targeted sites...The observed genomic damage in mitotically active cells caused by CRISPR–Cas9 editing may have pathogenic consequen
@largezygote @lcagee @elonmusk https://t.co/7fsjt5oFyO here is the article how shit is your daily use crispr.
RT @EpgntxEinstein: @RogerHighfield Pretty well known phenomenon at this stage, possibly first shown by Allan Bradley at the @sangerinstitu…
@RogerHighfield Pretty well known phenomenon at this stage, possibly first shown by Allan Bradley at the @sangerinstitute in 2018: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/aE0pc
RT @JeffK_BanGMOs: @nature Really? https://t.co/B9tgH1Jixs
RT @JeffK_BanGMOs: @nature Really? https://t.co/B9tgH1Jixs
RT @JeffK_BanGMOs: @nature Really? https://t.co/B9tgH1Jixs
RT @JeffK_BanGMOs: @nature Really? https://t.co/B9tgH1Jixs
@nature Really? https://t.co/B9tgH1Jixs
CRISPR-Cas9により誘導されたDBSの修復は広範な欠失や複雑な再構成を引き起こす ✔︎ これまでCRISPRの検索は標的領域周辺に限定された報告が多い ✔︎ ロングレンジgenotyping PCRにより疾患への関与も示唆 ✔︎ ゲノム編集の臨床応用にあたり包括的ゲノム解析が望ましい https://t.co/BqbuRqW68q
注目のゲノム編集技術クリスパー 特許の行方は:朝日新聞デジタル https://t.co/Y8xL6Eppbr CRISPR–Cas9は、大規模な削除と複雑さをもたらします。 https://t.co/goTTPwJbR1
@Hiddemhigh Maar nu dit: dergelijke artikels (peer review etc), baren me wel wat zorgen en dan vind ik een precautionary principle a priori niet slecht: https://t.co/85WZ2ozADV (bv als het tot meer voorzichtigheid en genoom wijdere analyses aanmaant alvore
ゲノム編集技術をがん治療に応用 米で臨床試験 https://t.co/VmUemRzC9r CRISPR–Cas9は合理的に特異的であり、マウス胚性幹細胞、マウス造血前駆細胞、ヒト分化細胞株の標的部位での大きな欠失やより複雑なゲノム再配列など、重要なオンターゲット変異誘発を報告している。 https://t.co/goTTPwJbR1
RT @AfrahBawazeer: ومازالت الدراسات مستمرة لمعرفة المزيد عن آثار مقص Cas9 في الخلايا قبل تطبيق تقنية CRISPR سريريا في علاج الأمراض. 📍المصد…
ومازالت الدراسات مستمرة لمعرفة المزيد عن آثار مقص Cas9 في الخلايا قبل تطبيق تقنية CRISPR سريريا في علاج الأمراض. 📍المصدر: https://t.co/f0WRSPPs9z
デザイナーベビーが現実に? 進む受精卵のゲノム編集:朝日新聞デジタル https://t.co/JZPZeJMfZW CRISPR–Cas9は、大規模な削除と複雑さをもたらします。 https://t.co/goTTPwJbR1
RT @AfrahBawazeer: في دراسةمثيرة البحث فيNature Biotechnology https://t.co/f0WRSPPs9z تم الكشف عن“انماط أخرى”من أنظمة CRISPR التي لاتتطلب ق…
RT @AfrahBawazeer: في دراسةمثيرة البحث فيNature Biotechnology https://t.co/f0WRSPPs9z تم الكشف عن“انماط أخرى”من أنظمة CRISPR التي لاتتطلب ق…
RT @AfrahBawazeer: في دراسةمثيرة البحث فيNature Biotechnology https://t.co/f0WRSPPs9z تم الكشف عن“انماط أخرى”من أنظمة CRISPR التي لاتتطلب ق…
RT @AfrahBawazeer: في دراسةمثيرة البحث فيNature Biotechnology https://t.co/f0WRSPPs9z تم الكشف عن“انماط أخرى”من أنظمة CRISPR التي لاتتطلب ق…
RT @AfrahBawazeer: في دراسةمثيرة البحث فيNature Biotechnology https://t.co/f0WRSPPs9z تم الكشف عن“انماط أخرى”من أنظمة CRISPR التي لاتتطلب ق…
@VMinneker Well... the potential on-target effects I’m looking at at the moment are in the kb scale (https://t.co/tyWepB0tFj). The problem with our samples is that they’re very valuable (single cells from early human embryos) and not amenable for long-read
@colindaven @yokofakun Long read WGS is an option too. The best of both worlds! Or at least long read the target site per @michaelkosicki’s work https://t.co/2gt9d8QM5g
RT @Peng_He_Caltech: CRISPR's dark side https://t.co/iTc44s92I2
RT @OrenoSource: ゲノム編集でDNA消失、新技術の信頼ゆらぐ 英チーム:朝日新聞デジタル https://t.co/QccUCll8AL オンターゲットサイトに欠失や大規模挿入が生じることがある Nat biotech原著↓ https://t.co/dnY0y…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @WagersScott: The stocks of gene editing companies tumbled when this article was published. It shows that CRISPR can cause more unintend…
ولإصلاح او إضافة جين : عند القطع يتم استبدال الجينات المعطلة بجينات سليمة معدلة أو جديدة. هذا باختصار عن تقنية كاسبر للتعديل الجيني .. https://t.co/1w6va56aNh
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @Jeroen_vdSluijs: @KirstenHnrds @BionextTweets @LauraBromet #RTGPlantgezondheid CRISPR Cas is niet precies https://t.co/rhasUEqZxU en in…
RT @Jeroen_vdSluijs: @KirstenHnrds @BionextTweets @LauraBromet #RTGPlantgezondheid CRISPR Cas is niet precies https://t.co/rhasUEqZxU en in…
RT @Jeroen_vdSluijs: @KirstenHnrds @BionextTweets @LauraBromet #RTGPlantgezondheid CRISPR Cas is niet precies https://t.co/rhasUEqZxU en in…
@KirstenHnrds @BionextTweets @LauraBromet #RTGPlantgezondheid CRISPR Cas is niet precies https://t.co/rhasUEqZxU en in hogere organismen al helemaal niet https://t.co/mTBwxRNaV4
RT @GaetanBurgio: What an interesting paper that just came out in @natureBiotech from Allan Bradley’s group @tombergk on #CRISPR & on-targe…
@Rvrprod @PrFeuillage @verre_d_eau @saprinti @Bunker_D_ @Ecolo @ph_lamberts @EELV @GreensEP @PhilippeBaret @yjadot @DeSchutterUNSR @HumaBio @HuetSylvestre @mathieuvidard @sfoucart @Curiolog Je ne vois pas très bien comment parler de science sur TW, mais j'
数え切れないほどの塩基配列の中で、数カ所変えれば全て良くなるってないよなあやっぱり。
@falla_alejandra This was on the cards, already reported before https://t.co/tnIoqAN7dC Just looking at a few sites (doing short length seq or normal PCR), and saying "No off-targets" only helps those trying to make money out of it... https://t.co/wRpjI
New from #wellcometrust https://t.co/au7lE2Gp4o Repair of CRISPR/Cas9-induced double-stranded breaks leads to large deletions and complex rearrangements
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
Interesting...
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements | Nature Biotechnology https://t.co/OUHM0oox9k
RT @AfrahBawazeer: في دراسةمثيرة البحث فيNature Biotechnology https://t.co/f0WRSPPs9z تم الكشف عن“انماط أخرى”من أنظمة CRISPR التي لاتتطلب ق…
@OmicsOmicsBlog @wcm_matt @Luigimoro69 @nanopore The more the better ! In fact studies that do it, do find these problems, for eg https://t.co/XrLqVb0XJp There should be the desire too to look in depth. In short reads, s/w just ignore unmapped - and then
@AgEngResearch @oxfordfarming But is not that clear cut, is it? — Repair of double strand breaks induced by CRISPR-Cas leads to large deletions and complex rearrangements https://t.co/qhFbt5T3Lh
RT @AboutMedtech: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/EZ…
RT @AboutMedtech: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/EZ…
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/plvmaRIRVL
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/EZaDlhZE8U
More bad news about CRISPR: a study in Nature Biotechnology suggests that the edits that CRISPR makes to your DNA might not be as accurate as previously thought, causing collateral damage. https://t.co/R1TuvUW15K https://t.co/PehPfHxDQP https://t.co/XdQL2Q
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
これまで、CRISPR-Cas9によるゲノム編集は標的部位に特異的なものであるとされていたが、マウスやヒトの細胞株での実験により、Cas9による編集が大規模な欠失や切断部位の遠位の傷害、交差現象等を引き起こし得ることが判明した。https://t.co/c3a0XK6rPZ HN
@Grey_Monroe It's very telling and not that smart to equate "CRISPR may not as precise as its boosters claim"https://t.co/tWdYB5uCel to "there's a big winter storm coming, and that means climate change is a hoax."