RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @jsantoyo: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements. https://t.co/m6Hpe…
Interesting https://t.co/YyXX51dszm
@GMWatch Prof. Maria Jasin: "This study shows that further research and specific testing is needed before CRISPR/Cas9 is used clinically" https://t.co/edqbOYZZze @NatureBiotech #TestBiotech #CRISPR #CRISPRCas9 #newgenetictechniques #nieuwegentechnieken #bi
RT @ProfPaulYoung: Ahhhh, well, OK that's.....interesting! Time to pull the CRISPR express train over and check the engine? https://t.co/Ib…
May want to cancel and rethink that order for a "designer baby." https://t.co/xttdVu6Pm7
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/6EadpAzlt2
Unexpected like a rainy day in UK! #CRISPR #offtarget https://t.co/8Q0Jtdo0rA
RT @FabianRChavez: A humbling reminder that although we have made important advances in our knowledge, there is still a lot we don't unders…
A humbling reminder that although we have made important advances in our knowledge, there is still a lot we don't understand. Don't forget, CRISPR was invented by bacteria, not us. https://t.co/siS2Lao3KF
@_BSGCT Maybe because of things like this? https://t.co/rut1RUq1SN
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @nresearchnews #CRISPR Cas9 #GenomeEditing can cause deletions and rearrangements near the target site: researchers overseeing therapies must closely monitor sequence changes in genome edited cells @NatureBiotech @sangerinstitute https://t.co/UKsN6tKLwx
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
In other words, total DNA scrambling in hideous and frightening ways that lead to the bizarre death of the organism. You want zombies? They're making them.
RT @ProfPaulYoung: Ahhhh, well, OK that's.....interesting! Time to pull the CRISPR express train over and check the engine? https://t.co/Ib…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @Aiims1742: Not the kind of news #CRISPR companies want to hear but there are large & complex ON TARGET deletions & rearrangements due t…
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements #CRISPR #geneediting #genome https://t.co/5EI86OqcAY
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
Hopefully, these are just the growing pains of new technologies and CRISPR does prove to be as high fidelity as we hoped once these issues are addressed.
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @JUNIUS_64: OOOOOOF. OOOOOOHHHFHH BOY. I WONDER HOW THAT GUY WHO GAVE HIMSELF A DIY CRISPR-CAS9 MYOSTATIN KNOCKOUT FEELS NOW https://t.c…
RT @klsywd: Today in @michelmorelab journal club we will be discussing this paper! #CRISPR I'll be live tweeting our discussion - so stay…
RT @tombergk: Our paper on unanticipated Cas9-directed genomic damage now out in @NatureBiotech. Major congrats to first author @michaelkos…
@Iori_Takamura https://t.co/YnoPJ2HnFL まあいうてなんとかなるべ
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @moorejh: A new paper in @NatureBiotech shows that #CRISPR may introduce more #DNA damage than previously understood that could in turn…
@MHendr1cks I don't know the politics here, but when we have tried CRISPR in vitro for simple gene KO, we have seen unexpected and random phenotypes not correlated with KO. Admittedly, we might not be great at it, but it does concern me. Also, see here:
RT @SFuntowicz: “CRISPR-Cas9 gene editing can cause unwanted DNA changes near target sites on the genome. The problem arises because cells…
RT @Chr1stenJohn: Gen-therapie is geen wondermiddel zonder risico's: CRISPR–Cas9 veroorzaakt breuken in het DNA. Herstel veroorzaakt grote…
RT @GaetanBurgio: What an interesting paper that just came out in @natureBiotech from Allan Bradley’s group @tombergk on #CRISPR & on-targe…
Extra cautiousness is warranted for stem cell CRISPR. It might also be a good approach to create more mutations/neoantigens to boost immune response as cancer cells usually mitotically active... https://t.co/t8cSWNWjRe
RT @SMBurgessLab: We need to check this in zebrafish. Most of our amplicons are <300bp https://t.co/K20NReasOo
RT @klsywd: Today in @michelmorelab journal club we will be discussing this paper! #CRISPR I'll be live tweeting our discussion - so stay…
RT @SFuntowicz: “CRISPR-Cas9 gene editing can cause unwanted DNA changes near target sites on the genome. The problem arises because cells…
RT @JUNIUS_64: OOOOOOF. OOOOOOHHHFHH BOY. I WONDER HOW THAT GUY WHO GAVE HIMSELF A DIY CRISPR-CAS9 MYOSTATIN KNOCKOUT FEELS NOW https://t.c…
RT @KhuranaLab: So it isn't that Crisp! https://t.co/QvLFtS7N0g
RT @tombergk: Our paper on unanticipated Cas9-directed genomic damage now out in @NatureBiotech. Major congrats to first author @michaelkos…
RT @michaelkosicki: We describe extensive Cas9-induced on-target genomic damage. Much of it missed by standard genotyping methods. Publishe…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
So it isn't that Crisp! https://t.co/QvLFtS7N0g
Deja vu? Worth following this story... - Repair of double-strand breaks induced by CRISPR-Cas9 leads to large deletions and complex rearrangements. - PubMed - NCBI https://t.co/X1DMvqdKwC
RT @ProfPaulYoung: Ahhhh, well, OK that's.....interesting! Time to pull the CRISPR express train over and check the engine? https://t.co/Ib…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
Landmark paper showing the importance of extensive genotyping after CRISPR editing https://t.co/P6aJmlKMYE
RT @DrEmmaJ: CRISPR/Cas9 and DNA damage - an important study with some important limitations. Undoubtedly outcomes should be examined caref…
Ahhhh, well, OK that's.....interesting! Time to pull the CRISPR express train over and check the engine?
CRISPR/Cas9: Not that selective? https://t.co/i16Ug3INkW
RT @DrEmmaJ: CRISPR/Cas9 and DNA damage - an important study with some important limitations. Undoubtedly outcomes should be examined caref…
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements | Nature Biotechnology https://t.co/M5zRTbNYB4 #DNA #Genetics #CRISPR #Genomics #Genes #Health #Medicine #Science #Technology #HealthCare
RT @moorejh: A new paper in @NatureBiotech shows that #CRISPR may introduce more #DNA damage than previously understood that could in turn…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @moorejh: A new paper in @NatureBiotech shows that #CRISPR may introduce more #DNA damage than previously understood that could in turn…
A new paper in @NatureBiotech shows that #CRISPR may introduce more #DNA damage than previously understood that could in turn be pathologic https://t.co/FlYEFNbgzv #genomics
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NCIgenomics: Study using long-read sequencing finds large deletions and complex rearrangements after #CRISPR/Cas9 induced double-strand…
RT @NCIgenomics: Study using long-read sequencing finds large deletions and complex rearrangements after #CRISPR/Cas9 induced double-strand…
Study using long-read sequencing finds large deletions and complex rearrangements after #CRISPR/Cas9 induced double-strand break and repair in mouse ES cells https://t.co/bJGOgnzY9Z https://t.co/BEfo0JyXfv
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @samstudio8: well it's like my mum always said, you shouldn't run around with scissors https://t.co/qFUbaQBDEM
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
In a blow to the gene editing super-tool CRISPR, scientists have found that it causes big, dangerous-looking changes to DNA in mouse and human cells https://t.co/9GZckwhljH
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @SMBurgessLab: We need to check this in zebrafish. Most of our amplicons are <300bp https://t.co/K20NReasOo
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @michaelkosicki: We describe extensive Cas9-induced on-target genomic damage. Much of it missed by standard genotyping methods. Publishe…
RT @strnr: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/aJkEvLxleP
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @veli_pet: Great work from one of the most thoughtful and hard-working young scinetists I know. Congratulations, @michaelkosicki! You re…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @OrenoSource: ゲノム編集でDNA消失、新技術の信頼ゆらぐ 英チーム:朝日新聞デジタル https://t.co/QccUCll8AL オンターゲットサイトに欠失や大規模挿入が生じることがある Nat biotech原著↓ https://t.co/dnY0y…
RT @BARBARtkowski: A blow to the #CRISPR fancy? https://t.co/2GLQnaPHgz
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/NGzgTjntlk
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
これから荒れそうですね。(別の言い方をすれば、盛り上がりそう。) 再現結果が沢山上がってくると思います。 もし消えるとして、消えやすいパターン等あればそれはそれでまた面白い。
well it's like my mum always said, you shouldn't run around with scissors https://t.co/qFUbaQBDEM
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @ZaminIqbal: "Using long-read sequencing and long-range PCR genotyping, we show that DNA breaks introduced by single-guide RNA/Cas9 freq…
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/kbqH4YwwN1
CRISPR/Cas9 and DNA damage - an important study with some important limitations. Undoubtedly outcomes should be examined carefully and techniques treated with caution, but this isn't the end for clinical CRISPR gene editing https://t.co/Qlb80KWe7X #CRISPR
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements | Nature Biotechnology https://t.co/udTH8kwlS2
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…