RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
Kosicki et. al. show that CRISPR/Cas9 (in its semi-original 2013 form) has significant genetic changes beyond the gRNA target. Need to know whether new Cas9 mutants are better?? #CRISPR #Science https://t.co/TAvvQxSvMp
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
@loliboldu això és cosa teva?
PSA reminder of @nntaleb's Precautionary Principle on decision making under fat tail probability distributions (often a result of top-down engineering and design, rather than bottom up evolutionary processes) https://t.co/yOXc4MrW8j https://t.co/9iCeVkfPK
RT @LluisMontoliu: A new study from Allan Bradley's lab at @sangerinstitute released today in @NatureBiotech further alerts of the large va…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
“In the clinical context of editing many billions of cells, the multitude of different mutations generated makes it likely that one or more edited cells in each protocol would be endowed with an important pathogenic lesion. “
How safe is #CRISPR #Cas9? Is there any damage due to #offtarget cutting? @michaelkosicki @tombergk & @sangerinstitute Allan Bradley tell us the latest findings in @NatureBiotech. https://t.co/Q2MzHOqIvB https://t.co/tKRPdpqq1K
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
Diprediksi jadi Gene Editing Tool termutakhir, CRISPR/CAS9 ternyata malah mengakibatkan delesi mutasi dan diperdebatkan keamanannya 🤔 Berikut laporan2nya:
Es #pseudociencia la ciencia miope, la basada en una causalidad local (Nicolescu)? El caso de los estudios de edición genética CRISPR como ejemplo: #Ciencia #Conocimiento https://t.co/TgyC3ITrC1 , https://t.co/qxlREJj7Qx , https://t.co/nZxbBFd8rC
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
@Pharma_BI
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
@percival_susan here is some of the latest on CRISPR-Cas9. There is always more to learn.
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @EricTopol: Questioning the real on-target specificity of #CRISPR genome editing https://t.co/nDT3o0L5pJ @NatureBiotech @sangerinstitut…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
Is CRISPR a safe approach for editing disease causing genes? Some caveats on co-lateral damage of non targeted genes are surfacing that question this https://t.co/5rmVrVXfLb https://t.co/zblY5ELXlt https://t.co/qD0KohiSH9
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/6Mm6QXblu6
Trialect has several traineeships on CRISPR–Cas9 genome editing. For those interested, please contact us at [email protected]@trialect.com">[email protected]>
@feross Soon, but not quite so soon :) https://t.co/DposaABC3T
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @JUNIUS_64: OOOOOOF. OOOOOOHHHFHH BOY. I WONDER HOW THAT GUY WHO GAVE HIMSELF A DIY CRISPR-CAS9 MYOSTATIN KNOCKOUT FEELS NOW https://t.c…
RT @nresearchnews: CRISPR–Cas9 genome editing can cause deletions and rearrangements near the target site. This finding suggests that resea…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @samstudio8: well it's like my mum always said, you shouldn't run around with scissors https://t.co/qFUbaQBDEM
Well darn... https://t.co/VxMSvqmLfq
RT @EricTopol: Questioning the real on-target specificity of #CRISPR genome editing https://t.co/nDT3o0L5pJ @NatureBiotech @sangerinstitut…
RT @EricTopol: Questioning the real on-target specificity of #CRISPR genome editing https://t.co/nDT3o0L5pJ @NatureBiotech @sangerinstitut…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @FabianRChavez: A humbling reminder that although we have made important advances in our knowledge, there is still a lot we don't unders…
KO is not that “easy” as those kits advertised. https://t.co/ktCv7uYhRa
RT @SouroullasLab: Has CRISPR-Cas9 off target DNA damage been underestimated? Scientist @sangerinstitute seem to think so. Check out @Natu…
RT @weldeiry: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/f8jqgm…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
@psuvafan007 @michaelkosicki @NatureBiotech Are you referring to this article? https://t.co/MB3LsqN1Fd
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @EricTopol: Questioning the real on-target specificity of #CRISPR genome editing https://t.co/nDT3o0L5pJ @NatureBiotech @sangerinstitut…
Welp!
Would be interesting to repeat with Cas9 nickases. Less likely to observe large indels as a result of single strand nicks. Cas9 nickases used in base editing technology - base editors can be used to correct point mutations implicated in many diseases wit
Enter biology: where debugging isn’t as simple as running IEx.pry. 📝: https://t.co/YpUB3P8mYq
RT @michaelkosicki: We describe extensive Cas9-induced on-target genomic damage. Much of it missed by standard genotyping methods. Publishe…
We need to control cas9 activity to achieve safer cell therapy products
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @EricTopol: Questioning the real on-target specificity of #CRISPR genome editing https://t.co/nDT3o0L5pJ @NatureBiotech @sangerinstitut…
RT @EricTopol: Questioning the real on-target specificity of #CRISPR genome editing https://t.co/nDT3o0L5pJ @NatureBiotech @sangerinstitut…
RT @EricTopol: Questioning the real on-target specificity of #CRISPR genome editing https://t.co/nDT3o0L5pJ @NatureBiotech @sangerinstitut…
RT @EricTopol: Questioning the real on-target specificity of #CRISPR genome editing https://t.co/nDT3o0L5pJ @NatureBiotech @sangerinstitut…
Here is the paper: https://t.co/L5kUR49a4S
This is so interesting and may lead to, well, um, CURES
RT @samstudio8: well it's like my mum always said, you shouldn't run around with scissors https://t.co/qFUbaQBDEM
Congrats @michaelkosicki and @tombergk .... Big splash indeed👍
RT @weldeiry: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/f8jqgm…
https://t.co/dyS4CHbCSS oops...
STUDY SHOWS: CRISPR Could Be Causing Extensive Mutations And Genetic Damage. https://t.co/dV76RSLhYT
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/f8jqgmKHz9 genetic deletions not limited to the target locus is cause for concern with CRISPR technology; caveat emptor
RT @HGF_Cath: Interesting article from the Wellcome Sanger Institute, it's certainly had an effect on stocks! https://t.co/1G6PcR3d0v
The stocks of gene editing companies tumbled when this article was published. It shows that CRISPR can cause more unintended DNA damage than was first thought. It is also an example of the challenges inherent to the #TranslationalGap https://t.co/PHvE1YQf
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @GaetanBurgio: What an interesting paper that just came out in @natureBiotech from Allan Bradley’s group @tombergk on #CRISPR & on-targe…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
Mini editoriale di Alessio Angeleri: Un'altra follia umana: l'editing del genoma con la tecnica CRISPR-CAS9. Questo complesso, che funge da sistema immunitario dei batteri, permette di creare una sorta di "registro" per riconoscere i... https://t.co/tHi9
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @ProfPaulYoung: Ahhhh, well, OK that's.....interesting! Time to pull the CRISPR express train over and check the engine? https://t.co/Ib…
CRISPR–Cas9 genome editing can cause deletions and rearrangements near the target site. This finding suggests that researchers overseeing CRISPR–Cas9-based human therapies must closely monitor sequence changes in genome-edited cells https://t.co/WDTKz4DDjf
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
@VirginiaGewin @TamarHaspel Not sure what you mean by transparency. Do you mean unintended consequences?Recent literature has shown that genome editing can affect genome in various ways as shown in https://t.co/JwvRfFS61S. Clearly, many will have issues wi
RT @EricTopol: Questioning the real on-target specificity of #CRISPR genome editing https://t.co/nDT3o0L5pJ @NatureBiotech @sangerinstitut…
“The observed genomic damage in mitotically active cells caused by CRISPR-Cas9 editing may have pathogenic consequences.” Gene editing is not without significant unpredictable risk. https://t.co/MrJPrNGInl
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @scilovers: Must read one👇 Repair of double-strand breaks induced by CrIsPr–Cas9 leads to large deletions and complex rearrangements. Na…
The study done by Dr. Allan Bradley's group has shown unwanted deletions produced by CRISPR gene editing. This should be considered by all scientists. https://t.co/5lva1aEUfX
RT @michaelkosicki: We describe extensive Cas9-induced on-target genomic damage. Much of it missed by standard genotyping methods. Publishe…
RT @FabianRChavez: A humbling reminder that although we have made important advances in our knowledge, there is still a lot we don't unders…
RT @OrenoSource: ゲノム編集でDNA消失、新技術の信頼ゆらぐ 英チーム:朝日新聞デジタル https://t.co/QccUCll8AL オンターゲットサイトに欠失や大規模挿入が生じることがある Nat biotech原著↓ https://t.co/dnY0y…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/A27oMQ4DtW