Today in @michelmorelab journal club we will be discussing this paper! #CRISPR I'll be live tweeting our discussion - so stay tuned!
@DieRobinsonDie it is also spectacular https://t.co/HNDo3lzOLy
RT @michaelkosicki: We describe extensive Cas9-induced on-target genomic damage. Much of it missed by standard genotyping methods. Publishe…
RT @CihanTastan_PhD: #CRISPR hisseleri yine çakıldı. $EDIT ↘️5% $CRSP ↘️6% $NTLA ↘️7% #CRISPR /Cas9 gen düzenlemesiyle oluşan genom hasar…
RT @minouye271: Oh boy, this looks big. $300M wiped off CRISPR company stocks. https://t.co/xxqznbtsdB https://t.co/70zMhm4jB2
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
Crisper not so benign after all, according to new study from Allan Bradley's group, pub in Nature Biotechnology https://t.co/jzzJRU5mo4
RT @van__Oijen: Another CRISPR crisis? CRISPR/Cas9 causes extensive genetic alterations, some of which undetected by standard genotyping a…
@cjrw @Nuffbioethics And this https://t.co/G1QFPHAFnE
Pointing out possible imperfections to the CRISPR gene editing method. Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements | Nature Biotechnology https://t.co/YFEnxeQiLl
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @SMBurgessLab: We need to check this in zebrafish. Most of our amplicons are <300bp https://t.co/K20NReasOo
RT @Aiims1742: Not the kind of news #CRISPR companies want to hear but there are large & complex ON TARGET deletions & rearrangements due t…
RT @Aiims1742: Not the kind of news #CRISPR companies want to hear but there are large & complex ON TARGET deletions & rearrangements due t…
Another paper describing safety concerns of CRISPR/Cas9 in human cells, possibly relevant for future therapeutic use of the technology. https://t.co/VdxOKltGXB https://t.co/zjG33Z9LHl
RT @GaetanBurgio: What an interesting paper that just came out in @natureBiotech from Allan Bradley’s group @tombergk on #CRISPR & on-targe…
RT @CircadianClocks: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co…
Repair of double-strand breaks induced by CRISPR-Cas9 leads to large deletions and complex rearrangements. https://t.co/6Tya9Ar9AI
RT @strnr: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/aJkEvLxleP
Informed commentary like this keeps me using Twitter! https://t.co/SbgTQOfbhH
RT @tombergk: Our paper on unanticipated Cas9-directed genomic damage now out in @NatureBiotech. Major congrats to first author @michaelkos…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @ZaminIqbal: "Using long-read sequencing and long-range PCR genotyping, we show that DNA breaks introduced by single-guide RNA/Cas9 freq…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tombergk: Our paper on unanticipated Cas9-directed genomic damage now out in @NatureBiotech. Major congrats to first author @michaelkos…
And here's the original paper if you are interested https://t.co/0DZ4ptKdsp https://t.co/h5Uzq5xqyW
RT @AndyBiotech: #CRISPR stocks getting rocked again... $EDIT -5% $CRSP -6% $NTLA -7% https://t.co/epeGNFxPLI Here is the new @NatureBiote…
CRISPR–Cas9 editing may have pathogenic consequences #tcellrx https://t.co/eLI0RwD7QY
"Kollateralschaden: Krebs" Neue #CRISPR-Studie schickt Aktien auf Talfahrt. Einschätzungen von @sciencezoe im #EchoderZeit. Hier die Studie: https://t.co/gJqQbC8pnn Hier das Gespräch: https://t.co/aY3KTaUrFH
RT @GaetanBurgio: What an interesting paper that just came out in @natureBiotech from Allan Bradley’s group @tombergk on #CRISPR & on-targe…
RT @tombergk: Our paper on unanticipated Cas9-directed genomic damage now out in @NatureBiotech. Major congrats to first author @michaelkos…
RT @FZMarques: A bit of a worry for a technique that promised to change the way genetic diseases are treated - is the hype of #CRISPR-Cas9…
RT @tombergk: Our paper on unanticipated Cas9-directed genomic damage now out in @NatureBiotech. Major congrats to first author @michaelkos…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @GenomeEditor: Stock traders spooked again by intuitive conclusions when inducing double stranded breaks. Cas9 based companies see vola…
Parece que empregar CRISPR/Cas9 na edição gênica não vai ser tão fácil assim... 🤔 https://t.co/VgooyUkRyp
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @GaetanBurgio: What an interesting paper that just came out in @natureBiotech from Allan Bradley’s group @tombergk on #CRISPR & on-targe…
Every innovation presents risks, advancement in gene editing shouldn't be turned away like atomic power was. https://t.co/gB7ZtmTNGF
RT @Aiims1742: Not the kind of news #CRISPR companies want to hear but there are large & complex ON TARGET deletions & rearrangements due t…
RT @CircadianClocks: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co…
RT @EricTopol: Questioning the real on-target specificity of #CRISPR genome editing https://t.co/nDT3o0L5pJ @NatureBiotech @sangerinstitut…
RT @GaetanBurgio: What an interesting paper that just came out in @natureBiotech from Allan Bradley’s group @tombergk on #CRISPR & on-targe…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
Genome damage from CRISPR/Cas9 gene editing higher than thought https://t.co/B8ekYCOfHy https://t.co/cnqzR9Pd6V via @physorg_com @NatureBiotech #biotechnology #crispr @CRISPRlab https://t.co/xekjoTRRYj
RT @michaelkosicki: We describe extensive Cas9-induced on-target genomic damage. Much of it missed by standard genotyping methods. Publishe…
"la edición de genes CRIsPR-Cas9 puede causar cambios de ADN no deseados cerca de los sitios de destino en el genoma...". https://t.co/cn9B63kKPJ… https://t.co/ZQvXP0ACI6
Het zal toch niet waar zijn?! Wat een verrassing. ;) @FederaMedWet https://t.co/34EEqFiwqX
Here we go again. Did anyone short the stock?? https://t.co/lraoDG8tVb
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @kavehdaneshvar: I wish I could keep up with the scientific literature like the Wall Street. One Nature Biotech paper is out and all the…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @veli_pet: Great work from one of the most thoughtful and hard-working young scinetists I know. Congratulations, @michaelkosicki! You re…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @GaetanBurgio: What an interesting paper that just came out in @natureBiotech from Allan Bradley’s group @tombergk on #CRISPR & on-targe…
Gen-therapie is geen wondermiddel zonder risico's: CRISPR–Cas9 veroorzaakt breuken in het DNA. Herstel veroorzaakt grote deleties en complexe rearrangementen. Risico op kanker en ongewenste mutaties https://t.co/F4QRaGYEQu https://t.co/w2obuvA9YP
RT @JUNIUS_64: OOOOOOF. OOOOOOHHHFHH BOY. I WONDER HOW THAT GUY WHO GAVE HIMSELF A DIY CRISPR-CAS9 MYOSTATIN KNOCKOUT FEELS NOW https://t.c…
No genetic miracle cures without side effects: CRISPR–Cas9 causes double-strand genomic breaks. Repair leads to large deletions and complex rearrangements. Risk for cancers and unwanted mutations. https://t.co/VV8L8rIhKb
RT @AndyBiotech: #CRISPR stocks getting rocked again... $EDIT -5% $CRSP -6% $NTLA -7% https://t.co/epeGNFxPLI Here is the new @NatureBiote…
RT @AndyBiotech: #CRISPR stocks getting rocked again... $EDIT -5% $CRSP -6% $NTLA -7% https://t.co/epeGNFxPLI Here is the new @NatureBiote…
“CRISPR-Cas9 gene editing can cause unwanted DNA changes near target sites on the genome. The problem arises because cells are not perfect at repairing the cuts that CRISPR makes in their DNA.” https://t.co/VRejdo8yPx
RT @rustenlab: Good reasons to include several independently CRISPR-CAS9-generated mutant lines study suggests. Not as clean as hoped for.…
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/oLX4yUGVhZ
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/h7UAg1znhD
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
https://t.co/HuQi6vWAFD perhaps a better #tweed
https://t.co/aq1wEprlBE #Genome #Editing with #Crispr not always a good #idea
RT @Aiims1742: Not the kind of news #CRISPR companies want to hear but there are large & complex ON TARGET deletions & rearrangements due t…
RT @mbelshazly: The complexity and ingenuity of #Biology never ceases to fascinate me. How will this affect the #CRISPR hype? First resista…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @JUNIUS_64: OOOOOOF. OOOOOOHHHFHH BOY. I WONDER HOW THAT GUY WHO GAVE HIMSELF A DIY CRISPR-CAS9 MYOSTATIN KNOCKOUT FEELS NOW https://t.c…
“Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements,” by Michael Kosicki, Kärt Tomberg & Allan Bradley, Nature Biotechnology; published online 16 July 2018; doi:10.1038/nbt.4192 https://t.co/B9tg
Kosicki et al found rearrangements after #CRISPR-#Cas9 editing in tissue culture. https://t.co/6CT8RvfpNI Do not assume cancer. #phiC31 integrase caused rearrangements too, but phiC31 #genetherapy did not shorten tumor latency. https://t.co/WCk4OijG5p T
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/ue6dlXrBEH
@VarditRavitsky what about : https://t.co/K2EeOjxjRx and https://t.co/xnuBStGLg0 ????
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
قلنا سابقا اي تدخل خارجي مصيره الفشل https://t.co/Otjtgee7UC
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
Le code génétique n'est pas un code informatique. La modification d'une séquence entraîne de multiples autres modifications, avec des conséquences ... et oui, la biologie ce n'est pas de l'informatique :) https://t.co/ELy0gRgs9Y
RT @GaetanBurgio: What an interesting paper that just came out in @natureBiotech from Allan Bradley’s group @tombergk on #CRISPR & on-targe…
RT @JUNIUS_64: OOOOOOF. OOOOOOHHHFHH BOY. I WONDER HOW THAT GUY WHO GAVE HIMSELF A DIY CRISPR-CAS9 MYOSTATIN KNOCKOUT FEELS NOW https://t.c…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
A new study published in Nature Biotechnology shows that on-target editing by CRISPR/Cas9 can result in large deletions and large kilobase genomic rearrangements in the genome. This genomic damage may be pathogenic. The study highlights the problem of... h
A new study published in Nature Biotechnology shows that on-target editing by CRISPR/Cas9 can result in large deletions and large kilobase genomic rearrangements in the genome. This genomic damage may be pathogenic. https://t.co/TNIBnmtHb4
Researchers from @sangerinstitute found that the DNA breaks induced by single-guide RNA-Cas9 led to kilobase-long deletions in about 20% of cells. Via @NatureBiotech https://t.co/r2DFohpphT
RT @pdhsu: Well-balanced article by @julemieux1 in @GENbio on new @NatureBiotech story from Allan Bradley's group on large CRISPR-Cas9 dele…