Long read sequencing to identify CRISPR mediated mutations and complex rearrangements. https://t.co/JLAXykRBXo
RT @evolvwing: This thread is a must read for all people out there doing #CRISPR. My takehome: 1) stop saying "NHEJ-repair of CRISPR/Cas9 i…
RT @GaetanBurgio: What an interesting paper that just came out in @natureBiotech from Allan Bradley’s group @tombergk on #CRISPR & on-targe…
RT @evolvwing: This thread is a must read for all people out there doing #CRISPR. My takehome: 1) stop saying "NHEJ-repair of CRISPR/Cas9 i…
RT @evolvwing: This thread is a must read for all people out there doing #CRISPR. My takehome: 1) stop saying "NHEJ-repair of CRISPR/Cas9 i…
RT @evolvwing: This thread is a must read for all people out there doing #CRISPR. My takehome: 1) stop saying "NHEJ-repair of CRISPR/Cas9 i…
RT @evolvwing: This thread is a must read for all people out there doing #CRISPR. My takehome: 1) stop saying "NHEJ-repair of CRISPR/Cas9 i…
@EdgeItn. As expected, feared, and predicted there seem to be off-target effects for CRISPR/Cas9 gene editing too.
RT @evolvwing: This thread is a must read for all people out there doing #CRISPR. My takehome: 1) stop saying "NHEJ-repair of CRISPR/Cas9 i…
RT @GaetanBurgio: What an interesting paper that just came out in @natureBiotech from Allan Bradley’s group @tombergk on #CRISPR & on-targe…
RT @evolvwing: This thread is a must read for all people out there doing #CRISPR. My takehome: 1) stop saying "NHEJ-repair of CRISPR/Cas9 i…
RT @evolvwing: This thread is a must read for all people out there doing #CRISPR. My takehome: 1) stop saying "NHEJ-repair of CRISPR/Cas9 i…
RT @chubbyemu: In modern times, whenever tech folks hype something up in context of medicine, it has hardly ever turned out, or caused more…
This thread is a must read for all people out there doing #CRISPR. My takehome: 1) stop saying "NHEJ-repair of CRISPR/Cas9 induces short indels" 2) intronic sgRNA can cause null-allele. 3) Don't infer mutant allele spectrum with short PCR genotyping https
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/tS7TeCg7rF
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @ATCGPartners: Unexpected #CRISPR on-target damages @michaelkosicki et al @sangerinstitute https://t.co/DKW3v84XZe As #HyunjiLee & #JinS…
RT @ATCGPartners: Unexpected #CRISPR on-target damages @michaelkosicki et al @sangerinstitute https://t.co/DKW3v84XZe As #HyunjiLee & #JinS…
RT @ATCGPartners: Unexpected #CRISPR on-target damages @michaelkosicki et al @sangerinstitute https://t.co/DKW3v84XZe As #HyunjiLee & #JinS…
RT @ATCGPartners: Unexpected #CRISPR on-target damages @michaelkosicki et al @sangerinstitute https://t.co/DKW3v84XZe As #HyunjiLee & #JinS…
RT @ATCGPartners: Unexpected #CRISPR on-target damages @michaelkosicki et al @sangerinstitute https://t.co/DKW3v84XZe As #HyunjiLee & #JinS…
RT @ATCGPartners: Unexpected #CRISPR on-target damages @michaelkosicki et al @sangerinstitute https://t.co/DKW3v84XZe As #HyunjiLee & #JinS…
RT @LeducPh: Et si l’édition du génome par la technique CRISPR/Cas 9 était loin de la panacée : risque d’endommager l’ADN autour de la zone…
RT @ATCGPartners: Unexpected #CRISPR on-target damages @michaelkosicki et al @sangerinstitute https://t.co/DKW3v84XZe As #HyunjiLee & #JinS…
RT @LeducPh: Et si l’édition du génome par la technique CRISPR/Cas 9 était loin de la panacée : risque d’endommager l’ADN autour de la zone…
RT @ATCGPartners: Unexpected #CRISPR on-target damages @michaelkosicki et al @sangerinstitute https://t.co/DKW3v84XZe As #HyunjiLee & #JinS…
Unexpected #CRISPR on-target damages @michaelkosicki et al @sangerinstitute https://t.co/DKW3v84XZe As #HyunjiLee & #JinSooKim @IBS_media point out "the authors raise the bar for safe use of CRISPR–Cas9 gene editing tools in #genetherapy" @NatureBiotec
RT @LeducPh: Et si l’édition du génome par la technique CRISPR/Cas 9 était loin de la panacée : risque d’endommager l’ADN autour de la zone…
RT @marthaherbertmd: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co…
Et si l’édition du génome par la technique CRISPR/Cas 9 était loin de la panacée : risque d’endommager l’ADN autour de la zone à modifier >> https://t.co/nXeiKJnTsH
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/AbeFrawWzd So much for "safe"....
RT @IFManchester: #nature #biotechnology Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearran…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
Cancelling my order of CRISPR kit to build muscles. If only @LastWeekTonight had covered CRISPR just two weeks later I would have never wasted that money. https://t.co/2EpgGkGAL4
Check yourself before you wreck yourself! CRISPR inducing up to 9kb dels, insertions of other genomic bits, and even crossing over of homologous chromosomes at an alarmingly high rate. #CRISPR https://t.co/2EpgGkGAL4
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
네이쳐도 챙겨볼까 좋네
Thread of studies and articles on CRISPR inaccuracies and collateral damage.
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
#nature #biotechnology Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements, research find on https://t.co/c5VntjTv03 https://t.co/YLxy6ahoVB
ゲノム編集でDNA消失、新技術の信頼ゆらぐ 英チーム:朝日新聞 https://t.co/oCvQSI5stf
RT @sejovirus: Required reading... https://t.co/ESmuvoYw54
RT @sejovirus: Required reading... https://t.co/ESmuvoYw54
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements #CRISPR #wakeupcall @DorothyDankel https://t.co/eZErZgNK6G
@RobertWager1 Hm. What's your take on this paper, which seems to have published basically in parallel to the paper in PLOSGenetics? https://t.co/OR8SMJDCkc
RT @jsoriamd: CRISPR-Cas9 can also cause significant genetic havoc... https://t.co/EfF1HL3Hcm https://t.co/66Oqim8ehi
@BioBeef Alison, any thoughts on this paper: https://t.co/d1jk7ns8tt Thanks.
RT @jsoriamd: CRISPR-Cas9 can also cause significant genetic havoc... https://t.co/EfF1HL3Hcm https://t.co/66Oqim8ehi
CRISPR-Cas9 can also cause significant genetic havoc... https://t.co/EfF1HL3Hcm https://t.co/66Oqim8ehi
@newscilive @KhuranaLab @DrHelenONeill Not yet!! Great advances..Should come with disclaimers for common folk. https://t.co/76VEkaUWmN https://t.co/9I7hUGNSLd
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
Very interesting, incredibly valuable study by @Allan_Bradley' group: Is CRISPR-Cas9 as precise as it is assumed: https://t.co/yPdvHa8ZCy
a great paper on CRISPR-Cas9 and its possibly pathogenic off-target effect #genome @NatureNews #medicine @guardianscience https://t.co/5shzKHuW0f https://t.co/apMvlgwF6W
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
@PonderingSci " FA pathway does not directly impact error-prone, non-homologous end joining", so the worries from Sanger paper holds... https://t.co/h3QX3evGXD Taken further, the concept of using "FANCD2 to map off-targets" wont hold, since it wont be r
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/mYphH5ktXV
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @AdamMead_Oxford: CRISPR-Cas9 is not always as precise as we thought. Important study. https://t.co/PiAsKNvQpl
CRISPR-Cas9 is not always as precise as we thought. Important study.
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @KnowmadInstitut: Freshly published research has brought to the fore data on the dangers of CRISPR-Cas9, which could cause significantly…
RT @KnowmadInstitut: Una investigación recién publicada ha puesto en la palestra un datos sobre los peligros del CRISPR-Cas9 , el cual pod…
Published: 16 July 2018 Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/05nyFk77nk
Freshly published research has brought to the fore data on the dangers of CRISPR-Cas9, which could cause significantly more genetic damage than experts have until now estimated. https://t.co/kFaqu2tuqa
Una investigación recién publicada ha puesto en la palestra un datos sobre los peligros del CRISPR-Cas9 , el cual podría causar un daño genético significativamente mayor de lo que los expertos calculaban hasta ahora. https://t.co/kFaqu2tuqa
RT @GaetanBurgio: What an interesting paper that just came out in @natureBiotech from Allan Bradley’s group @tombergk on #CRISPR & on-targe…
ゲノム編集でDNA消失、新技術の信頼ゆらぐ 英チーム:朝日新聞 https://t.co/oCvQSI5stf
RT @GaetanBurgio: What an interesting paper that just came out in @natureBiotech from Allan Bradley’s group @tombergk on #CRISPR & on-targe…
"Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements" https://t.co/NsC6xcrVNq
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/KfYplGmu7J https://t.co/BnGNf3XW7d
@M_Huenninghaus @daswasfehlt @greenpeace_de Aber momentan ist crispr sowieso noch nicht praktisch anwendbar wg. dem aktuell festgestellten und noch nicht gelösten Problem dass durch crispr aktivierte DNA double-strand break Reparatur ungewollte DNA Verände
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/s5YV6c6yF8 https://t.co/AOwPft5lFD
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/4rUJliH08P https://t.co/pFTLlHlSCg
Mas problemillas para #CRISPR habrá que seguir investigando sus posibles efectos adversos ☣ https://t.co/WqpCi088si
Oh, merda. https://t.co/IBiAIkouds
RT @PlantEvolution: I reserve judgment. Read the paper thoroughly and am convinced that this is what was observed, but I would like to see…
El uso de técnicas CRIPSPR para "reescribir" el ADN y eliminar mutaciones malignas provoca delecciones importantes en otros fragmentos del ADN, incluso muy lejanos. Un golpe muy muy duro a esta técnica. https://t.co/eFi4RsFvui
RT @PlantEvolution: I reserve judgment. Read the paper thoroughly and am convinced that this is what was observed, but I would like to see…
RT @MrChylo: Ups. CRISPR-Cas9 provoca deleciones amplias del genoma en zonas alejadas del gen que se está editando. @elenagomezdiaz @josefr…
¿Ves @JROteroAsman ?
🤔 Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements #CRISPR #Genetics 🔬 https://t.co/VV8V7YnaPI
Ups. CRISPR-Cas9 provoca deleciones amplias del genoma en zonas alejadas del gen que se está editando. @elenagomezdiaz @josefra1975 https://t.co/fakizTsQLn #in https://t.co/luNyfKzTdQ
La técnica de edición genética CRISPR genera mutaciones amplias en el genoma. [Eng.] https://t.co/RdMZKQI45y
RT @plantsciences: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/b…
RT @PlantEvolution: I reserve judgment. Read the paper thoroughly and am convinced that this is what was observed, but I would like to see…
RT @PlantEvolution: I reserve judgment. Read the paper thoroughly and am convinced that this is what was observed, but I would like to see…
RT @PlantEvolution: I reserve judgment. Read the paper thoroughly and am convinced that this is what was observed, but I would like to see…
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/d1jk7ns8tt
CRISPR's latest failures should not be confused with gene therapy, innovation, and other treatments that are flourishing. #biotech #biopharma https://t.co/FwC9ODaW7c
RT @PlantEvolution: I reserve judgment. Read the paper thoroughly and am convinced that this is what was observed, but I would like to see…
I reserve judgment. Read the paper thoroughly and am convinced that this is what was observed, but I would like to see an equivalent experiment in plants: single sgRNA targeting UTR or intron, ask how often that gives a KO phenotype (need haploinsufficient