RT @Aiims1742: Not the kind of news #CRISPR companies want to hear but there are large & complex ON TARGET deletions & rearrangements due t…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
@everydayfight13 @statnews Sorry for slow response, paper too technical for me to really understand so was waiting for responses from scientists. Although it's also fairly technical, just saw this thread on twitter: https://t.co/qQe5Jd9XJg - sounds concern
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tombergk: Our paper on unanticipated Cas9-directed genomic damage now out in @NatureBiotech. Major congrats to first author @michaelkos…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements. https://t.co/m6Hpe0B9CS
...y así creamos a los mutantes de Fallout. https://t.co/mS56NKOZJ3
RT @tombergk: Our paper on unanticipated Cas9-directed genomic damage now out in @NatureBiotech. Major congrats to first author @michaelkos…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @Magda_Skipper: #CRISPR gene editing produces unwanted DNA deletions https://t.co/gXqyWuLGBl @naturenews | original research @NatureBiot…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @minouye271: Oh boy, this looks big. $300M wiped off CRISPR company stocks. https://t.co/xxqznbtsdB https://t.co/70zMhm4jB2
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
@jeannefrances more journal club article on CRISPR? 😰guess CRISPR company stocks are probably down again 😓 https://t.co/epn1DEYDhP
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tombergk: Our paper on unanticipated Cas9-directed genomic damage now out in @NatureBiotech. Major congrats to first author @michaelkos…
RT @tombergk: Our paper on unanticipated Cas9-directed genomic damage now out in @NatureBiotech. Major congrats to first author @michaelkos…
Ver todo el hilo con fallas de CRISPR, muy buen trabajo para entender los alcances de esta tecnología. https://t.co/QhqGjWWbAz
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @ZaminIqbal: "Using long-read sequencing and long-range PCR genotyping, we show that DNA breaks introduced by single-guide RNA/Cas9 freq…
RT @Aiims1742: Not the kind of news #CRISPR companies want to hear but there are large & complex ON TARGET deletions & rearrangements due t…
RT @tombergk: Our paper on unanticipated Cas9-directed genomic damage now out in @NatureBiotech. Major congrats to first author @michaelkos…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @yamagatm3: 「信頼がゆらぐ」のではなくて、皆知っていることで、単に説明できないことや説明しにくいことは、論文にならないので、こういう情報が共有されていないということに過ぎないのでは。実際に実験していない教授や生命倫理学者みたいな人の考えや感覚に頼るのは問題とい…
RT @yamagatm3: これが元論文なのだが、こういうのって実際にやっている人なら知っていることだと思う。私も、こういう感じの現象は何度も体験してきている。 https://t.co/B44ClfBTzu https://t.co/iaDw6c7ZBi
I guess designer babies are still a ways off yet https://t.co/BOwqD4HyQc
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @GaetanBurgio: What an interesting paper that just came out in @natureBiotech from Allan Bradley’s group @tombergk on #CRISPR & on-targe…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @JUNIUS_64: honestly this illustrates a really important cautionary tale in biology don’t assume that just because you can’t see it, s…
Every #science experiment needs controls. https://t.co/txjx9FqH40
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @SMBurgessLab: We need to check this in zebrafish. Most of our amplicons are <300bp https://t.co/K20NReasOo
Refers to this Nature Biotech study "Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements" https://t.co/4qmu5IQHdi #CRISPR #GenomeEditing
We need to check this in zebrafish. Most of our amplicons are <300bp https://t.co/K20NReasOo
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
Finally a paper showing the extent to which Cas9 editing can damage the genome. https://t.co/qzHwx3fpzp
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tombergk: Our paper on unanticipated Cas9-directed genomic damage now out in @NatureBiotech. Major congrats to first author @michaelkos…
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/CUpyPno8rw https://t.co/ccIjrjKPKt
RT @sejovirus: Required reading... https://t.co/ESmuvoYw54
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @GaetanBurgio: What an interesting paper that just came out in @natureBiotech from Allan Bradley’s group @tombergk on #CRISPR & on-targe…
Good reasons to include several independently CRISPR-CAS9-generated mutant lines study suggests. Not as clean as hoped for. https://t.co/YgVD800736
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
Based on my ~6 years of CRISPR experience in mouse ESCs and embryos, I would have titled this paper "CRISPR-Cas9 leads to cool and unexpected mutations" https://t.co/Uy5EM0S0fN
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @JUNIUS_64: honestly this illustrates a really important cautionary tale in biology don’t assume that just because you can’t see it, s…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @LluisMontoliu: @tinitun Hola Ramón, ya he comentado esta publicación en este hilo: https://t.co/9mBCobGzR8
honestly this illustrates a really important cautionary tale in biology don’t assume that just because you can’t see it, something isn’t happening https://t.co/elcLpRzJqX
#CRISPR is not quite as benign as supposed, with the possibility of large deletions or rearrangement. Meanwhile there are #clinicaltrials of this technology. https://t.co/cAA9yTWZPp
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @michaelkosicki: We describe extensive Cas9-induced on-target genomic damage. Much of it missed by standard genotyping methods. Publishe…
Crispr teknolojisinin tedavide kullanımı biraz sıkıntıya girdi. Yeni yayınlanan makalede büyük çaplı gen editlemesi, bazı hücrelerde büyük gen silinmeleri ya da komplex genomik yeniden düzenlemelere yol açıyormuş. https://t.co/5UH9yooXuT
RT @GaetanBurgio: What an interesting paper that just came out in @natureBiotech from Allan Bradley’s group @tombergk on #CRISPR & on-targe…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @michaelkosicki: We describe extensive Cas9-induced on-target genomic damage. Much of it missed by standard genotyping methods. Publishe…
RT @GaetanBurgio: What an interesting paper that just came out in @natureBiotech from Allan Bradley’s group @tombergk on #CRISPR & on-targe…
RT @yamagatm3: これが元論文なのだが、こういうのって実際にやっている人なら知っていることだと思う。私も、こういう感じの現象は何度も体験してきている。 https://t.co/B44ClfBTzu https://t.co/iaDw6c7ZBi
Uh-oh 😢 https://t.co/1pfqjNQwkr
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
All is not well ... Did you expect anything less? https://t.co/akTS9CdrrJ
RT @ARanganathan72: Hi Dr Tomberg, congrats for this landmark paper. One question: would you recommend whole genome sequencing of cell-line…
#geneediting should not be in clinical trials before one can prove by WG sequencing that no off-target mutation is generated. $EDIT $NTLA $CRSP are playing with fire. If off-target mutations were discovered in clinical trials, #GeneTherapy will be set back
Turns out CRISPR editing can also vandalize genomes https://t.co/e3GGreCtHM
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @veli_pet: Great work from one of the most thoughtful and hard-working young scinetists I know. Congratulations, @michaelkosicki! You re…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
Something to consider and be aware of. https://t.co/O1DYktrVwO
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @EricTopol: Questioning the real on-target specificity of #CRISPR genome editing https://t.co/nDT3o0L5pJ @NatureBiotech @sangerinstitut…
Eh?!! https://t.co/3inS4ITNl9
RT @tombergk: Our paper on unanticipated Cas9-directed genomic damage now out in @NatureBiotech. Major congrats to first author @michaelkos…
RT @minouye271: Oh boy, this looks big. $300M wiped off CRISPR company stocks. https://t.co/xxqznbtsdB https://t.co/70zMhm4jB2