RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @HGF_Cath: Interesting article from the Wellcome Sanger Institute, it's certainly had an effect on stocks! https://t.co/1G6PcR3d0v
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
A blow to the #CRISPR fancy? https://t.co/2GLQnaPHgz
RT @rustenlab: Good reasons to include several independently CRISPR-CAS9-generated mutant lines study suggests. Not as clean as hoped for.…
Letter in nature biotechnology: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/UV0KctElqN #CRISPR https://t.co/Q13iKhcas4
RT @tombergk: Our paper on unanticipated Cas9-directed genomic damage now out in @NatureBiotech. Major congrats to first author @michaelkos…
Letter in nature biotechnology: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/huQ3PEMK9z #CRISPR https://t.co/evgzGhgy3v
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @AndyBiotech: #CRISPR stocks getting rocked again... $EDIT -5% $CRSP -6% $NTLA -7% https://t.co/epeGNFxPLI Here is the new @NatureBiote…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @SFuntowicz: “CRISPR-Cas9 gene editing can cause unwanted DNA changes near target sites on the genome. The problem arises because cells…
The pitfalls of #CRISPR-Cas9 genome editing https://t.co/ME82WzxAXi
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @michaelkosicki: We describe extensive Cas9-induced on-target genomic damage. Much of it missed by standard genotyping methods. Publishe…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @EricTopol: Questioning the real on-target specificity of #CRISPR genome editing https://t.co/nDT3o0L5pJ @NatureBiotech @sangerinstitut…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @klsywd: Today in @michelmorelab journal club we will be discussing this paper! #CRISPR I'll be live tweeting our discussion - so stay…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
After all, it’s not all ponies and rainbows! #nofreelunch hits back :) https://t.co/NPpHM8Xs4B
A massive boost for the viral vector gene therapy field! Certainly with the news that the repair of double-strand breaks induced by CRISPR–Cas9 can lead to large deletions and complex rearrangements (https://t.co/V2VOYparzE) https://t.co/yIG42i77Eq
@aemonten @ppgardne And then this came out! A lot can change in a couple of days. Upshot - we need to do more work to get to the bottom of the off-target effects. https://t.co/nxyPCZDWJS
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
"The observed genomic damage in mitotically active cells caused by CRISPR–Cas9 editing may have pathogenic consequences." https://t.co/m0MopuFgWO
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @michaelkosicki: We describe extensive Cas9-induced on-target genomic damage. Much of it missed by standard genotyping methods. Publishe…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
Damage potential underestimated for high-flying CRISPR? Double-stranded break repairs by the system induce large deletions and complex genome arrangements. #crispr-cas9 #GenomeEditing @sangerinstitute https://t.co/PH0KvW0UEo
RT @rajivxgulati: Worrying? https://t.co/PLW5L8t0Nf @KUDeanSimari @jhfrudd @HenrytTimothy @FaroucJaffer
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tombergk: Our paper on unanticipated Cas9-directed genomic damage now out in @NatureBiotech. Major congrats to first author @michaelkos…
RT @klsywd: Today in @michelmorelab journal club we will be discussing this paper! #CRISPR I'll be live tweeting our discussion - so stay…
The first hit on CRISPR https://t.co/x5Was2k5Lt
RT @klsywd: Today in @michelmorelab journal club we will be discussing this paper! #CRISPR I'll be live tweeting our discussion - so stay…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @minouye271: Oh boy, this looks big. $300M wiped off CRISPR company stocks. https://t.co/xxqznbtsdB https://t.co/70zMhm4jB2
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @rustenlab: Good reasons to include several independently CRISPR-CAS9-generated mutant lines study suggests. Not as clean as hoped for.…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @iGEM_IITM: Uh-oh 😢 https://t.co/1pfqjNQwkr
RT @CircadianClocks: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co…
RT @SFuntowicz: “CRISPR-Cas9 gene editing can cause unwanted DNA changes near target sites on the genome. The problem arises because cells…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @JUNIUS_64: OOOOOOF. OOOOOOHHHFHH BOY. I WONDER HOW THAT GUY WHO GAVE HIMSELF A DIY CRISPR-CAS9 MYOSTATIN KNOCKOUT FEELS NOW https://t.c…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @GaetanBurgio: I have something to add to this. You certainly all remember this paper from Ma et al. from Mitalipov group in @nature on…
RT @GaetanBurgio: What an interesting paper that just came out in @natureBiotech from Allan Bradley’s group @tombergk on #CRISPR & on-targe…
RT @GaetanBurgio: I have something to add to this. You certainly all remember this paper from Ma et al. from Mitalipov group in @nature on…
RT @guruccb: I couldn't stop 🤣 after reading this tweet https://t.co/nXHTOwTS0b
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
Oops! https://t.co/9dzSa3bjxV
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
Genome lesions of large deletions and rearrangements by #CRISPR-Cas9 will block the pace of genetic therapy: https://t.co/RxS1UEu81a. #sciencenews https://t.co/Zl3pijRTcd
RT @klsywd: Today in @michelmorelab journal club we will be discussing this paper! #CRISPR I'll be live tweeting our discussion - so stay…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
I always wondered about off-target (by-product) gene changes from CRISPR. This paper reinforces those fears.
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @JUNIUS_64: OOOOOOF. OOOOOOHHHFHH BOY. I WONDER HOW THAT GUY WHO GAVE HIMSELF A DIY CRISPR-CAS9 MYOSTATIN KNOCKOUT FEELS NOW https://t.c…
Tudo indica que utilizaremos a #CRISPR como terapia, mas os estudos indicam que é necessário mais conhecimento do CRISPR-Cas9 Como se diz no interior: "Devagar com o andor" https://t.co/8MTqDnUDdw
I'm glad my committee asked me early on to look into literature for how to address/detect off target effects. It made me realize early on that sensitivity and accuracy for detection was not there yet. https://t.co/B3Z4nCC0oC
RT @JUNIUS_64: OOOOOOF. OOOOOOHHHFHH BOY. I WONDER HOW THAT GUY WHO GAVE HIMSELF A DIY CRISPR-CAS9 MYOSTATIN KNOCKOUT FEELS NOW https://t.c…
RT @OrenoSource: ゲノム編集でDNA消失、新技術の信頼ゆらぐ 英チーム:朝日新聞デジタル https://t.co/QccUCll8AL オンターゲットサイトに欠失や大規模挿入が生じることがある Nat biotech原著↓ https://t.co/dnY0y…
RT @klsywd: Today in @michelmorelab journal club we will be discussing this paper! #CRISPR I'll be live tweeting our discussion - so stay…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @GaetanBurgio: What an interesting paper that just came out in @natureBiotech from Allan Bradley’s group @tombergk on #CRISPR & on-targe…
RT @tombergk: Our paper on unanticipated Cas9-directed genomic damage now out in @NatureBiotech. Major congrats to first author @michaelkos…
RT @tuuliel: We've seen the exact same thing in my lab, and it's a huge headache. Great to have this properly documented and published. Con…
RT @GaetanBurgio: What an interesting paper that just came out in @natureBiotech from Allan Bradley’s group @tombergk on #CRISPR & on-targe…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @klsywd: Today in @michelmorelab journal club we will be discussing this paper! #CRISPR I'll be live tweeting our discussion - so stay…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @NatureBiotech: Repair of double-strand breaks induced by #CRISPR–Cas9 leads to large deletions and complex rearrangements https://t.co/…
RT @klsywd: Today in @michelmorelab journal club we will be discussing this paper! #CRISPR I'll be live tweeting our discussion - so stay…