| Chapter title |
A Geneticist’s View of Prostate Cancer: Prostate Cancer Treatment Considerations
|
|---|---|
| Chapter number | 8 |
| Book title |
Cell & Molecular Biology of Prostate Cancer
|
| Published in |
Advances in experimental medicine and biology, September 2018
|
| DOI | 10.1007/978-3-319-95693-0_8 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-995692-3, 978-3-31-995693-0
|
| Authors |
Abraham Eisenstark, Eisenstark, Abraham |
| Abstract |
Prostate cancer remains a life-threatening disease of men. While early detection has been helpful to reduce the mortality rate, we currently do not have a desired therapy. In recent years, new strategies have been proposed to treat prostate cancers with poor prognosis by utilizing genetically modified bacteria, including Salmonella typhimurium that preferentially replicate within solid tumors (1000:1 and up to 10,000:1 compared to non-cancerous tissue) destroying cancer cells without causing septic shock that is typically associated with wild-type S. typhimurium infections. Furthermore, these bacteria have the potential to be utilized as drug delivery systems to more effectively target different subpopulations of prostate tumor cells. This chapter reviews progress in using genetically modified S. typhimurium for destruction of prostate tumors. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 14 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 36% |
| Student > Ph. D. Student | 2 | 14% |
| Student > Doctoral Student | 1 | 7% |
| Student > Master | 1 | 7% |
| Unknown | 5 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 21% |
| Immunology and Microbiology | 2 | 14% |
| Computer Science | 1 | 7% |
| Social Sciences | 1 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
| Other | 0 | 0% |
| Unknown | 6 | 43% |